Pancreatic β cell identity requires continual repression of non-β cell programs.
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The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult miceGenetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage developmentMetabolic Stress and Compromised Identity of Pancreatic Beta Cells.The undoing and redoing of the diabetic β-cell.Beta cell heterogeneity: an evolving concept.Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.The RhoGAP Stard13 controls insulin secretion through F-actin remodeling.Nrf2/antioxidant pathway mediates β cell self-repair after damage by high-fat diet-induced oxidative stress.β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells.Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells.β Cells led astray by transcription factors and the company they keep.Diabetes: Controlling the identity of the adult pancreatic β cell.Single-cell analyses of human islet cells reveal de-differentiation signatures.The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes.Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cellsLong Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes
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Pancreatic β cell identity requires continual repression of non-β cell programs.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 December 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Pancreatic β cell identity requires continual repression of non-β cell programs.
@en
Pancreatic β cell identity requires continual repression of non-β cell programs.
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type
label
Pancreatic β cell identity requires continual repression of non-β cell programs.
@en
Pancreatic β cell identity requires continual repression of non-β cell programs.
@nl
prefLabel
Pancreatic β cell identity requires continual repression of non-β cell programs.
@en
Pancreatic β cell identity requires continual repression of non-β cell programs.
@nl
P2093
P2860
P356
P1476
Pancreatic β cell identity requires continual repression of non-β cell programs
@en
P2093
Aaron S Bender
Giselle Domínguez Gutiérrez
Klaus H Kaestner
Lori Sussel
Stephen M Kelly
Teresa L Mastracci
Vincenzo Cirulli
P2860
P304
P356
10.1172/JCI88017
P407
P577
2016-12-12T00:00:00Z