Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects - Wikidata - awgldk - TriplyDB

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

http://www.wikidata.org/entity/Q37550216

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Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer Disruptive CHD8 mutations define a subtype of autism early in development SETD2: an epigenetic modifier with tumor suppressor functionality The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility.Genomic aberrations frequently alter chromatin regulatory genes in chordoma.A Multidisciplinary Biospecimen Bank of Renal Cell Carcinomas Compatible with Discovery Platforms at Mayo Clinic, Scottsdale, Arizona.Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity.Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells.Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer.Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span.Histone H3.3 and cancer: A potential reader connection.High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility.CAME: identification of chromatin accessibility from nucleosome occupancy and methylome sequencing.SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.Loss of histone H3 lysine 36 trimethylation is associated with an increased risk of renal cell carcinoma-specific death Connecting the dots: chromatin and alternative splicing in EMT.Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease.Histone H3K36 methylation regulates pre-mRNA splicing in Saccharomyces cerevisiae Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma Insights into the Genetic Basis of the Renal Cell Carcinomas from The Cancer Genome Atlas.Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.RNA splicing factors as oncoproteins and tumour suppressors.SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer.Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma.An emerging understanding of long noncoding RNAs in kidney cancer.Examining the impact of gene variants on histone lysine methylation A global assessment of cancer genomic alterations in epigenetic mechanisms.BAP1, PBRM1 and SETD2 in clear-cell renal cell carcinoma: molecular diagnostics and possible targets for personalized therapies.Distinct molecular profile of diffuse cerebellar gliomas.Intron retention in mRNA: No longer nonsense: Known and putative roles of intron retention in normal and disease biology.Alternative splicing: the pledge, the turn, and the prestige : The key role of alternative splicing in human biological systems.Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation Dual Chromatin and Cytoskeletal Remodeling by SETD2.Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma.Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing.H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development

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Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

http://www.wikidata.org/entity/Q37550216

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 24 October 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Variation in chromatin accessi ...... espread RNA processing defects

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Variation in chromatin accessi ...... spread RNA processing defects.

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type

label

Variation in chromatin accessi ...... espread RNA processing defects

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Variation in chromatin accessi ...... spread RNA processing defects.

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prefLabel

Variation in chromatin accessi ...... espread RNA processing defects

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Variation in chromatin accessi ...... spread RNA processing defects.

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Genome Research

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Variation in chromatin accessi ...... espread RNA processing defects

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A Rose Brannon

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Darshan Singh

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Eric Jonasch

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Ian J Davis

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Jan F Prins

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Jason D Lieb

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Jeremy M Simon

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Joel S Parker

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Kathryn E Hacker

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Matthew Weiser

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Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

The human SWI/SNF subunit Brm is a regulator of alternative splicing

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

The accessible chromatin landscape of the human genome

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

State of the science: an update on renal cell carcinoma

Fast and accurate short read alignment with Burrows-Wheeler transform

TopHat: discovering splice junctions with RNA-Seq

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241-250

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scholarly article

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10.1101/GR.158253.113

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2

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24

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Terrence S. Furey

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2013-10-24T00:00:00Z

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258044245

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24158655

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3912414

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