Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.

Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.

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http://www.wikidata.org/entity/Q37553149
Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressorPygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasiaThe BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesisAkt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells.Breast cancer stem cells.Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer.Selective estrogen receptor modulators and betulinic acid act synergistically to target ERα and SP1 transcription factor dependent Pygopus expression in breast cancer.Pygo2 siRNA Inhibit the Growth and Increase Apoptosis of U251 Cell by Suppressing Histone H3K4 Trimethylation.Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger.Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors.Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway.Increased Pygo2 expression in liver of patients with hepatitis B virus-related fibrosis.
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Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.

Item
http://www.wikidata.org/entity/Q37553149
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 January 2013
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Chromatin effector Pygo2 regul ...... terogeneity in MMTV-Wnt1 mice.
@en
Chromatin effector Pygo2 regul ...... terogeneity in MMTV-Wnt1 mice.
@nl
type
label
Chromatin effector Pygo2 regul ...... terogeneity in MMTV-Wnt1 mice.
@en
Chromatin effector Pygo2 regul ...... terogeneity in MMTV-Wnt1 mice.
@nl
prefLabel
Chromatin effector Pygo2 regul ...... terogeneity in MMTV-Wnt1 mice.
@en
Chromatin effector Pygo2 regul ...... terogeneity in MMTV-Wnt1 mice.
@nl
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P1476
P2093
P2860
P2888
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P356
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P433
P478
P577
P5875
P698
P932
P356
P1433
P1476
Chromatin effector Pygo2 regul ...... terogeneity in MMTV-Wnt1 mice.
@en
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P932