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The basal transcription machinery as a target for cancer therapySgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitinationSGF29 and Sry pathway in hepatocarcinogenesisNuclear roles and regulation of chromatin structure by the stress-dependent MAP kinase Sty1 of Schizosaccharomyces pombeStructural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.Structural Insights into the Assembly and Function of the SAGA Deubiquitinating ModuleA Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and ActivitySgf29p facilitates the recruitment of TATA box binding protein but does not alter SAGA's global structural integrity in vivo.Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.Activation of a poised RNAPII-dependent promoter requires both SAGA and mediator.The TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation.Unveiling novel interactions of histone chaperone Asf1 linked to TREX-2 factors Sus1 and Thp1.A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.Poly(Q) Expansions in ATXN7 Affect Solubility but Not Activity of the SAGA Deubiquitinating ModuleIdentification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion libraryNot5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGAA novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression.Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complexSus1p facilitates pre-initiation complex formation at the SAGA-regulated genes independently of histone H2B de-ubiquitylationHistone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrityLoss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription.K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formationDistinct regulatory mechanisms of eukaryotic transcriptional activation by SAGA and TFIID.An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control.Chromatin dynamics during DNA replicationThe Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae.Histone modifiers in cancer: friends or foes?Hypoxia elicits broad and systematic changes in protein subcellular localization.Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.Interplay among Gcn5, Sch9 and mitochondria during chronological aging of wine yeast is dependent on growth conditions.Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex in Plants: Genome Wide Identification, Evolutionary Conservation and Functional DeterminationThe Transition of Poised RNA Polymerase II to an Actively Elongating State Is a "Complex" Affair.Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6pAggregation of Polyglutamine-expanded Ataxin 7 Protein Specifically Sequesters Ubiquitin-specific Protease 22 and Deteriorates Its Deubiquitinating Function in the Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex.Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes.Nucleosome occupancy at transcription start sites in the human malaria parasite: a hard-wired evolution of virulence?
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Insights into SAGA function during gene expression
@en
Insights into SAGA function during gene expression.
@nl
type
label
Insights into SAGA function during gene expression
@en
Insights into SAGA function during gene expression.
@nl
prefLabel
Insights into SAGA function during gene expression
@en
Insights into SAGA function during gene expression.
@nl
P2860
P356
P1433
P1476
Insights into SAGA function during gene expression
@en
P2093
Susana Rodríguez-Navarro
P2860
P304
P356
10.1038/EMBOR.2009.168
P577
2009-07-17T00:00:00Z