Human clearance prediction: shifting the paradigm.

Human clearance prediction: shifting the paradigm.

Item
http://www.wikidata.org/entity/Q37554400
Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs)A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data.Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance.Drug structure-transport relationshipsRenal clearance in drug discovery and development: molecular descriptors, drug transporters and disease state.Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review.The right compound in the right assay at the right time: an integrated discovery DMPK strategy.Prediction of drug disposition on the basis of its chemical structure.Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing.Approaches to intravenous clinical pharmacokinetics: Recent developments with isotopic microtracers.Application of PBPK modelling in drug discovery and development at Pfizer.Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.Prediction of hepatic plasma clearance in vivo from gel-entrapped rat and human hepatocytes.Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds.Transporters in Drug Discovery
P2860

Human clearance prediction: shifting the paradigm.

Item
http://www.wikidata.org/entity/Q37554400
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Human clearance prediction: shifting the paradigm.
@en
Human clearance prediction: shifting the paradigm.
@nl
type
label
Human clearance prediction: shifting the paradigm.
@en
Human clearance prediction: shifting the paradigm.
@nl
prefLabel
Human clearance prediction: shifting the paradigm.
@en
Human clearance prediction: shifting the paradigm.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Human clearance prediction: shifting the paradigm.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698