Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.
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A quarter century of granzymesRecombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of themGranzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibitionHumoral and cellular immune response to RNA immunization with flavivirus replicons derived from tick-borne encephalitis virus.Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice.Hepatitis B and Hepatitis C Virus Replication Upregulates Serine Protease Inhibitor Kazal, Resulting in Cellular Resistance to Serine Protease-Dependent ApoptosisRNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammationGranzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity.Caspase-dependent inhibition of mousepox replication by gzmB.Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins.NK cells and apoptosis.Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Perforin is essential for control of ectromelia virus but not related poxviruses in mice.CD8 T cells use IFN-γ to protect against the lethal effects of a respiratory poxvirus infection.The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiologyGranzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice.Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection.In vivo elimination of MHC-I-deficient lymphocytes by activated natural killer cells is independent of granzymes A and B.Granzyme A activates another way to dieCell-mediated cytotoxicity in recovery from poxvirus infections.Perforin-mediated target-cell death and immune homeostasis.Death by a thousand cuts: granzyme pathways of programmed cell deathPerforin deficiency and susceptibility to cancer.Perforin: structure, function, and role in human immunopathology.Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function.How to induce involuntary suicide: the need for dipeptidyl peptidase I.Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosisComparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicityEnhanced resistance in STAT6-deficient mice to infection with ectromelia virusIn vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells.A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense.Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.Correlates of protective immunity in poxvirus infection: where does antibody stand?The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression.Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infectionDifferential expression of granzyme B and C in murine cytotoxic lymphocytes.Granzymes and caspase 3 play important roles in control of gammaherpesvirus latencyNK cell intrinsic regulation of MIP-1α by granzyme M
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P2860
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Granzyme A is critical for rec ...... ic viral pathogen, ectromelia.
@en
Granzyme A is critical for rec ...... ic viral pathogen, ectromelia.
@nl
type
label
Granzyme A is critical for rec ...... ic viral pathogen, ectromelia.
@en
Granzyme A is critical for rec ...... ic viral pathogen, ectromelia.
@nl
prefLabel
Granzyme A is critical for rec ...... ic viral pathogen, ectromelia.
@en
Granzyme A is critical for rec ...... ic viral pathogen, ectromelia.
@nl
P2093
P2860
P356
P1476
Granzyme A is critical for rec ...... ic viral pathogen, ectromelia.
@en
P2093
Blanden RV
Museteanu C
Müllbacher A
P2860
P304
P356
10.1073/PNAS.93.12.5783
P407
P577
1996-06-01T00:00:00Z