New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels.
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Reaction trajectory revealed by a joint analysis of protein data bankCO Rebinding Kinetics and Molecular Dynamics Simulations Highlight Dynamic Regulation of Internal Cavities in Human CytoglobinTertiary and Quaternary Allostery in Tetrameric Hemoglobin from Scapharca inaequivalvisStructure of fully liganded Hb ζ2β2strapped in a tense conformationFrom protein structure to function via single crystal optical spectroscopyUnfolding of Green Fluorescent Protein mut2 in wet nanoporous silica gels.Evidence of discrete substates and unfolding pathways in green fluorescent protein.NO reactions with sol-gel and solution phase samples of the ferric nitrite derivative of HbAHaemoglobin-based oxygen carriers: research and reality towards an alternative to blood transfusions.Heme reactivity is uncoupled from quaternary structure in gel-encapsulated hemoglobin: a resonance Raman spectroscopic study.Experimental basis for a new allosteric model for multisubunit proteins.Ligation tunes protein reactivity in an ancient haemoglobin: kinetic evidence for an allosteric mechanism in Methanosarcina acetivorans protoglobin.Tracking unfolding and refolding of single GFPmut2 molecules.Ligand migration through hemeprotein cavities: insights from laser flash photolysis and molecular dynamics simulations.Unsuspected pathway of the allosteric transition in hemoglobinThe tertiary origin of the allosteric activation of E. coli glucosamine-6-phosphate deaminase studied by sol-gel nanoencapsulation of its T conformer.In Silico Adoption of an Orphan Nuclear Receptor NR4A1Viscosity-dependent protein dynamicsLigand recombination and a hierarchy of solvent slaved dynamics: the origin of kinetic phases in hemeproteins.Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models.A quantum-chemical picture of hemoglobin affinityCircular dichroism spectroscopy of tertiary and quaternary conformations of human hemoglobin entrapped in wet silica gels.Molecular dynamics simulations of hemoglobin A in different states and bound to DPG: effector-linked perturbation of tertiary conformations and HbA concerted dynamicsModulation of reactivity and conformation within the T-quaternary state of human hemoglobin: the combined use of mutagenesis and sol-gel encapsulation.Dynamics of proteins encapsulated in silica sol-gel glasses studied with IR vibrational echo spectroscopyHarnessing allostery: a novel approach to drug discovery.Conformational selection or induced fit? 50 years of debate resolved.Tertiary and quaternary structural basis of oxygen affinity in human hemoglobin as revealed by multiscale simulations.An Origin of Cooperative Oxygen Binding of Human Adult Hemoglobin: Different Roles of the α and β Subunits in the α2β2 TetramerDifferential control of heme reactivity in alpha and beta subunits of hemoglobin: a combined Raman spectroscopic and computational study.ATP binding to human serine racemase is cooperative and modulated by glycine.Structure of liganded T-state haemoglobin from cat (Felis silvestris catus), a low oxygen-affinity species, in two different crystal forms.Tertiary dynamics of human adult hemoglobin fixed in R and T quaternary structures.Nitrite reductase activity of sol-gel-encapsulated deoxyhemoglobin. Influence of quaternary and tertiary structure.Hemoglobin Reactivity and RegulationTrapping Hemoglobin in Rigid Matrices: Fine Tuning of Oxygen Binding Properties by Modulation of Encapsulation ProtocolsConfinement and crowding effects on tryptophan synthase α2β2complexEntrapment and characterization of functional allosteric conformers of hemocyanin in sol–gel matrices
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P2860
New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 22 September 2004
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vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
New insights into allosteric m ...... conformations in silica gels.
@en
New insights into allosteric m ...... conformations in silica gels.
@nl
type
label
New insights into allosteric m ...... conformations in silica gels.
@en
New insights into allosteric m ...... conformations in silica gels.
@nl
prefLabel
New insights into allosteric m ...... conformations in silica gels.
@en
New insights into allosteric m ...... conformations in silica gels.
@nl
P2860
P50
P356
P1476
New insights into allosteric m ...... conformations in silica gels.
@en
P2093
William A Eaton
P2860
P304
14414-14419
P356
10.1073/PNAS.0405987101
P407
P577
2004-09-22T00:00:00Z