Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.
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Reconstitution reveals the functional core of mammalian eIF3Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assemblyFunctional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codonsHuman Cytomegalovirus Strategies to Maintain and Promote mRNA TranslationEukaryote-specific extensions in ribosomal proteins of the small subunit: Structure and functionWhy is start codon selection so precise in eukaryotes?'Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs)Eukaryotic initiation factor (eIF) 1 carries two distinct eIF5-binding faces important for multifactor assembly and AUG selectionStructural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexesStructure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complexSequential eukaryotic translation initiation factor 5 (eIF5) binding to the charged disordered segments of eIF4G and eIF2β stabilizes the 48S preinitiation complex and promotes its shift to the initiation mode.Molecular architecture of the 40S⋅eIF1⋅eIF3 translation initiation complexThe RNA recognition motif of eukaryotic translation initiation factor 3g (eIF3g) is required for resumption of scanning of posttermination ribosomes for reinitiation on GCN4 and together with eIF3i stimulates linear scanning.Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast.A mechanistic overview of translation initiation in eukaryotesFunctional analysis of individual binding activities of the scaffold protein eIF4GTranslation reinitiation and development are compromised in similar ways by mutations in translation initiation factor eIF3h and the ribosomal protein RPL24Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosomeIdentification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery.Rps5-Rps16 communication is essential for efficient translation initiation in yeast S. cerevisiae.Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex.Functional and biochemical characterization of human eukaryotic translation initiation factor 3 in living cells.Phosphorylation stoichiometries of human eukaryotic initiation factorsThe indispensable N-terminal half of eIF3j/HCR1 cooperates with its structurally conserved binding partner eIF3b/PRT1-RRM and with eIF1A in stringent AUG selectionEukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complexThe eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivoThe C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4GInitiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit.The mechanism of eukaryotic translation initiation: new insights and challengesSmall ribosomal protein RPS0 stimulates translation initiation by mediating 40S-binding of eIF3 via its direct contact with the eIF3a/TIF32 subunit.Eukaryotic translation initiation factor 5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation.Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeastDissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.Molecular mechanism of scanning and start codon selection in eukaryotes.N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selectionOn the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation.The eIF3c/NIP1 PCI domain interacts with RNA and RACK1/ASC1 and promotes assembly of translation preinitiation complexes.
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Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Interactions of eukaryotic tra ...... egulate start codon selection.
@en
Interactions of eukaryotic translation initiation factor 3
@nl
type
label
Interactions of eukaryotic tra ...... egulate start codon selection.
@en
Interactions of eukaryotic translation initiation factor 3
@nl
prefLabel
Interactions of eukaryotic tra ...... egulate start codon selection.
@en
Interactions of eukaryotic translation initiation factor 3
@nl
P2093
P2860
P1476
Interactions of eukaryotic tra ...... egulate start codon selection.
@en
P2093
Alan G Hinnebusch
Christie A Fekete
Klaus H Nielsen
Leos Valásek
P2860
P304
P356
10.1128/MCB.24.21.9437-9455.2004
P407
P577
2004-11-01T00:00:00Z