RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.
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Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice.Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular Dysfunction.The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP AssemblyAltered mRNA Splicing in SMN-Depleted Motor Neuron-Like Cells.Aberrant splicing in maize rough endosperm3 reveals a conserved role for U12 splicing in eukaryotic multicellular development.Faulty RNA splicing: consequences and therapeutic opportunities in brain and muscle disorders.Developmental regulation of SMN expression: pathophysiological implications and perspectives for therapy development in spinal muscular atrophy.Therapeutic strategies for spinal muscular atrophy: SMN and beyond.Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model.In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology.Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA.RNA-binding proteins in neurodegeneration: mechanisms in aggregate.CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN.SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities.Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy.mRNP assembly, axonal transport, and local translation in neurodegenerative diseases.Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology.Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA.Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors
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RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 August 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
RNA-sequencing of a mouse-mode ...... cing of U12-dependent introns.
@en
RNA-sequencing of a mouse-mode ...... cing of U12-dependent introns.
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label
RNA-sequencing of a mouse-mode ...... cing of U12-dependent introns.
@en
RNA-sequencing of a mouse-mode ...... cing of U12-dependent introns.
@nl
prefLabel
RNA-sequencing of a mouse-mode ...... cing of U12-dependent introns.
@en
RNA-sequencing of a mouse-mode ...... cing of U12-dependent introns.
@nl
P2093
P2860
P50
P356
P1476
RNA-sequencing of a mouse-mode ...... cing of U12-dependent introns.
@en
P2093
Adrian R Krainer
Anna Wieckowska
Gitte Hoffmann Bruun
Henriette Skovgaard Andersen
Sabrina Brøner
Ying Hsiu Liu
P2860
P304
P356
10.1093/NAR/GKW731
P407
P577
2016-08-23T00:00:00Z