The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts. - Wikidata - awgldk - TriplyDB

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

http://www.wikidata.org/entity/Q37578050

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Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology Boning up on autophagy: the role of autophagy in skeletal biology Paget disease of bone-associated UBA domain mutations of SQSTM1 exert distinct effects on protein structure and function Alternative splicing in osteoclasts and Paget's disease of bone.Emerging strategies and therapies for treatment of Paget's disease of bone.Role of NF-κB in the skeleton Mutant p62P392L stimulation of osteoclast differentiation in Paget's disease of bone Autophagy proteins regulate the secretory component of osteoclastic bone resorption.Polymorphisms in autophagy genes are associated with paget disease of bone.Paget's Disease of Bone: A Review of Epidemiology, Pathophysiology and Management Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease.Gene expression profile in osteoclasts from patients with Paget's disease of bone.The adaptor protein p62/SQSTM1 in osteoclast signaling pathways.Pathogenesis of Paget disease of bone.Osteosarcoma: Molecular Pathogenesis and iPSC Modeling.Further Evidence of Contrasting Phenotypes Caused by Reciprocal Deletions and Duplications: Duplication of NSD1 Causes Growth Retardation and Microcephaly.Behavioral effects of SQSTM1/p62 overexpression in mice: support for a mitochondrial role in depression and anxiety Autophagy and 3-Phosphoinositide-Dependent Kinase 1 (PDK1)-Related Kinome in Pagetic Osteoclasts.Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of patients with Paget's disease of bone.Lipopolysaccharide (LPS)-Induced Autophagy Is Responsible for Enhanced Osteoclastogenesis.Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.Autophagy: a new player in skeletal maintenance?Modulation of tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors in a human osteoclast model in vitro.p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget's disease-like bone phenotypes in mice.Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62 mouse model of Paget's disease Rab GTPases in Osteoclastic Endomembrane Systems Can zebrafish be a valid model to study Paget's disease of bone?

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P2860

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

http://www.wikidata.org/entity/Q37578050

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 09 July 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

@en

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

@nl

type

label

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

@en

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

@nl

prefLabel

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

@en

The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

@nl

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Molecular Endocrinology

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The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts.

@en

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Estelle Chamoux

http://www.w3.org/2001/XMLSchema#string

Jacques P Brown

http://www.w3.org/2001/XMLSchema#string

Jean Morissette

http://www.w3.org/2001/XMLSchema#string

Julie Couture

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Martine Bisson

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Sophie Roux

http://www.w3.org/2001/XMLSchema#string

P2860

Structure and functional properties of the ubiquitin binding protein p62

Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

RANKL-induced DC-STAMP is essential for osteoclastogenesis

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Osteoclast differentiation and activation

TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src.

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype.

Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease.

p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget's disease of bone.

P304

1668-1680

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scholarly article

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10.1210/ME.2009-0066

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10

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23

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2009-07-09T00:00:00Z

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26658999

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19589897

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5224938

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