Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
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The progress of early growth response factor 1 and leukemiaCDK6 as a key regulator of hematopoietic and leukemic stem cell activationA novel acquired inv(2)(p23.3q24.3) with concurrent submicroscopic deletions at 2p23.3, 2p22.1, 2q24.3 and 1p13.2 in a patient with chronic thrombocytopenia and anemiaThe genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemiaHaploinsufficient tumor suppressor genes.A novel insertion ins(18;5)(q21.1;q31.2q35.1) in acute myeloid leukemia associated with microdeletions at 5q31.2, 5q35.1q35.2 and 18q12.3q21.1 detected by oligobased array comparative genomic hybridizationRole of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1).Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes.A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignanciesmiR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer.Recurrent genetic defects on chromosome 5q in myeloid neoplasms.Molecular mechanisms of the progression of myelodysplastic syndrome to secondary acute myeloid leukaemia and implication for therapy.Therapy-related myeloid neoplasms: when genetics and environment collide.β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q).Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1.3D hotspots of recurrent retroviral insertions reveal long-range interactions with cancer genes.Loss of Egr1, a human del5q gene, accelerates BCR-ABL driven chronic myelogenous leukemia.Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.Clinical impact of KMT2C and SPRY4 expression levels in intensively treated younger adult acute myeloid leukemia patients.Gene expression profiling and construction of a putative gene regulatory network of bladder cancer tumor-initiating cells.Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation.Acute myeloid leukemiaThe conserved protective cyclic AMP-phosphodiesterase function PDE4B is expressed in the adenoma and adjacent normal colonic epithelium of mammals and silenced in colorectal cancer
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Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Haploinsufficiency of del(5q) ...... cute myeloid leukemia in mice.
@en
Haploinsufficiency of del(5q) ...... cute myeloid leukemia in mice.
@nl
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Haploinsufficiency of del(5q) ...... cute myeloid leukemia in mice.
@en
Haploinsufficiency of del(5q) ...... cute myeloid leukemia in mice.
@nl
prefLabel
Haploinsufficiency of del(5q) ...... cute myeloid leukemia in mice.
@en
Haploinsufficiency of del(5q) ...... cute myeloid leukemia in mice.
@nl
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Haploinsufficiency of del(5q) ...... cute myeloid leukemia in mice.
@en
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Angela Stoddart
Anthony A Fernald
Elizabeth M Davis
Jianghong Wang
John Anastasi
Michelle M Le Beau
Theodore Karrison
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P304
P356
10.1182/BLOOD-2013-07-517953
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P577
2013-12-31T00:00:00Z