Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts.
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Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin LIsolation and sequence of a cDNA for human pro-(cathepsin L)Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblastsThe identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitorThe identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin LAltered processing of a major secreted phosphoprotein correlates with tumorigenicity in Rous sarcoma virus-transformed mammalian cells.Decreased susceptibility of a 70-kDa protein to cathepsin L after phosphorylation by protein kinase C.Transformation stimulates glucose transporter gene expression in the absence of protein kinase CProcessing and activation of lysosomal proteinases.The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes.Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulatedCathepsin L targeting in cancer treatment.An acid protease secreted by transformed cells interferes with antigen processingModulation of the transport of a lysosomal enzyme by PDGF.Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cellsTransformation-related antigens identified by monoclonal antibodies.Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts.Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.Effect of carbohydrate position on lysosomal transport of procathepsin L.Malignant transformation and tumor promoter treatment increase levels of a transcript for a secreted glycoproteinRegulation of the transcript for a lysosomal protein: evidence for a gene program modified by platelet-derived growth factorIdentification of a BALB/c-3T3 cell protein modulated by platelet-derived growth factor.Platelet-derived growth factor-modulated translatable mRNAs.Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts.Conditioned medium from ras oncogene-transformed NIH 3T3 cells induces bone resorption in vitro.Quantification of cathepsins B and L in cells.Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.
P2860
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P2860
Transformation-dependent secretion of a low molecular weight protein by murine fibroblasts.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1978
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Transformation-dependent secre ...... protein by murine fibroblasts.
@en
Transformation-dependent secre ...... protein by murine fibroblasts.
@nl
type
label
Transformation-dependent secre ...... protein by murine fibroblasts.
@en
Transformation-dependent secre ...... protein by murine fibroblasts.
@nl
prefLabel
Transformation-dependent secre ...... protein by murine fibroblasts.
@en
Transformation-dependent secre ...... protein by murine fibroblasts.
@nl
P2860
P356
P1476
Transformation-dependent secre ...... protein by murine fibroblasts.
@en
P2093
Gottesman MM
P2860
P304
P356
10.1073/PNAS.75.6.2767
P407
P577
1978-06-01T00:00:00Z