Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.
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New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of AutophagyRoles of autophagy induced by natural compounds in prostate cancerPiperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast CancerPiperlongumine induces apoptosis and synergizes with cisplatin or paclitaxel in human ovarian cancer cells.Piperlongumine-induced phosphatidylserine translocation in the erythrocyte membraneDesign and synthesis of N-acylated aza-goniothalamin derivatives and evaluation of their in vitro and in vivo antitumor activity.Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP.Discovery of piperlongumine as a potential novel lead for the development of senolytic agents.Piperlongumine and its analogs down-regulate expression of c-Met in renal cell carcinoma.Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells.Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence.Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models.Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells.Untangling knots between autophagic targets and candidate drugs, in cancer therapy.Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells.Piperlongumine induces gastric cancer cell apoptosis and G2/M cell cycle arrest both in vitro and in vivo.Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway.Autophagy and Tubular Cell Death in the Kidney.Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells.The Clinical Potential of Senolytic Drugs.Vitamin K and its analogs: Potential avenues for prostate cancer management.Piperlongumine reverses doxorubicin resistance through the PI3K/Akt signaling pathway in K562/A02 human leukemia cells.Cellular proliferation and differentiation induced by single-layer molybdenum disulfide and mediation mechanisms of proteins via the Akt-mTOR-p70S6K signaling pathway.Natural agents mediated autophagic signal networks in cancer.Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models.Urban fine particulate matter (PM2.5) exposure destroys blood-testis barrier (BTB) integrity through excessive ROS-mediated autophagy.Piperlongumine induces apoptosis and autophagy in leukemic cells through targeting the PI3K/Akt/mTOR and p38 signaling pathways.Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models.The convergent roles of NF-κB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma.DEHP exposure destroys blood-testis barrier (BTB) integrity of immature testes through excessive ROS-mediated autophagy
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Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 16 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Piperlongumine promotes autoph ...... nd mediates cancer cell death.
@en
Piperlongumine promotes autoph ...... nd mediates cancer cell death.
@nl
type
label
Piperlongumine promotes autoph ...... nd mediates cancer cell death.
@en
Piperlongumine promotes autoph ...... nd mediates cancer cell death.
@nl
prefLabel
Piperlongumine promotes autoph ...... nd mediates cancer cell death.
@en
Piperlongumine promotes autoph ...... nd mediates cancer cell death.
@nl
P2093
P2860
P356
P1476
Piperlongumine promotes autoph ...... nd mediates cancer cell death.
@en
P2093
A Corcoran
K Golovine
R Mehrazin
V M Kolenko
P2860
P2888
P304
P356
10.1038/BJC.2013.810
P407
P577
2014-01-16T00:00:00Z