The p38alpha kinase plays a central role in inflammation.
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The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolismPyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cellsSkepinone-L is a selective p38 mitogen-activated protein kinase inhibitorT-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathwayEarly activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampiEarly effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytesChiral kinase inhibitors.Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cellsp38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cellsPan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cellsGlobal analyses of Chromosome 17 and 18 genes of lung telocytes compared with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes.p38 MAP Kinase Inhibition Reduces Propionibacterium acnes-Induced Inflammation in VitroA muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila.Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling.Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy.Lovastatin induces neuroprotection by inhibiting inflammatory cytokines in 6-hydroxydopamine treated microglia cellsGenetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms.The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.NF90 coordinately represses the senescence-associated secretory phenotype.MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammationInhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model.Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effectsIncreased oxidative stress response in granulocytes from older patients with a hip fracture may account for slow regeneration.Flow cytometric detection of p38 MAPK phosphorylation and intracellular cytokine expression in peripheral blood subpopulations from patients with autoimmune rheumatic diseases.Beyond ATM: the protein kinase landscape of the DNA damage response.The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look.Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond.Mitogen-activated protein kinases as therapeutic targets for rheumatoid arthritis.The miR-17 ∼ 92 Cluster: A Key Player in the Control of Inflammation during Rheumatoid Arthritis.First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.Multi-glycoside of Tripterygium wilfordii Hook. f. attenuates glomerulosclerosis in a rat model of diabetic nephropathy by exerting anti-microinflammatory effects without affecting hyperglycemia.Phenolic excipients of insulin formulations induce cell death, pro-inflammatory signaling and MCP-1 release.The MAP kinase p38 is part of Drosophila melanogaster's circadian clock.X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-ß1/Smad3 and p38 MAPK pathwaySynthetic phosphorylation of p38α recapitulates protein kinase activityComparative amino acid decomposition analysis of potent type I p38α inhibitors.Population pharmacokinetics of losmapimod in healthy subjects and patients with rheumatoid arthritis and chronic obstructive pulmonary diseases.
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The p38alpha kinase plays a central role in inflammation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The p38alpha kinase plays a central role in inflammation.
@en
The p38alpha kinase plays a central role in inflammation.
@nl
type
label
The p38alpha kinase plays a central role in inflammation.
@en
The p38alpha kinase plays a central role in inflammation.
@nl
prefLabel
The p38alpha kinase plays a central role in inflammation.
@en
The p38alpha kinase plays a central role in inflammation.
@nl
P1476
The p38alpha kinase plays a central role in inflammation.
@en
P2093
Gary L Schieven
P304
P356
10.2174/156802609789630974
P577
2009-01-01T00:00:00Z