Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. - Wikidata - awgldk - TriplyDB

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

http://www.wikidata.org/entity/Q37596359

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Mevalonate kinase deficiency: current perspectives Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway Molecular mechanisms regulating NLRP3 inflammasome activation Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders Initiation and perpetuation of NLRP3 inflammasome activation and assembly Immunologic manifestations of autophagy Hyper-IgD syndrome/mevalonate kinase deficiency: what is new?Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice Keeping the immune system in check: a role for mitophagy.Increased expression of IL-18 in the serum and islets of type 1 diabetics.NLRP3 inflammasome activation in dialyzed chronic kidney disease patients.Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation Effect of lycopene against gastroesophageal reflux disease in experimental animals Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse.Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects.Monogenic autoinflammatory diseases.Regulation of innate immunity by the molecular machinery of macroautophagy.Role of inflammasomes in intestinal inflammation and Crohn's disease.Perception of self: distinguishing autoimmunity from autoinflammation.Protein misfolding and dysregulated protein homeostasis in autoinflammatory diseases and beyond.Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2.Autoinflammatory Syndromes in Children.Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?Microglia activation and interaction with neuronal cells in a biochemical model of mevalonate kinase deficiency.Unprenylated RhoA contributes to IL-1β hypersecretion in mevalonate kinase deficiency model through stimulation of Rac1 activity.Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds.Mitochondrial DNA in innate immune responses and inflammatory pathology.The interplay between autophagy and tumorigenesis: exploiting autophagy as a means of anticancer therapy.Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34(+) Hematopoietic Stem-Progenitor Cells.Clinical update on inflammasomopathies.TLR2/TLR4-dependent exaggerated cytokine production in hyperimmunoglobulinaemia D and periodic fever syndrome.Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases.Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease.Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation.Knockdown of MVK does not lead to changes in NALP3 expression or activation.The Role of Monocyte Percentage in Osteoporosis in Male Rheumatic Diseases.Autophagy dysfunction in autoinflammatory diseases.

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Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion.

http://www.wikidata.org/entity/Q37596359

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 19 December 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Defects in mitochondrial clear ...... interleukin-1β hypersecretion.

@en

Defects in mitochondrial clear ...... interleukin-1β hypersecretion.

@nl

type

label

Defects in mitochondrial clear ...... interleukin-1β hypersecretion.

@en

Defects in mitochondrial clear ...... interleukin-1β hypersecretion.

@nl

prefLabel

Defects in mitochondrial clear ...... interleukin-1β hypersecretion.

@en

Defects in mitochondrial clear ...... interleukin-1β hypersecretion.

@nl

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JBC.M113.536920

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Journal of Biological Chemistry

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Defects in mitochondrial clear ...... interleukin-1β hypersecretion

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Joost Frenkel

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Kalliopi Pervolaraki

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Lieneke H Jongeneel

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Lotte Nijhuis

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Marielle van Gijn

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Paul J Coffer

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Pier G Mastroberardino

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Robert van der Burgh

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P2860

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

Autophagosomes form at ER-mitochondria contact sites

Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease

Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Autophagy fights disease through cellular self-digestion

A role for mitochondria in NLRP3 inflammasome activation

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

Regulation mechanisms and signaling pathways of autophagy

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10.1074/JBC.M113.536920

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8

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Michael P. Murphy

Ewoud B Compeer

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2013-12-19T00:00:00Z

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