A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.
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Purification, properties, and characterization of recombinant Streptomyces sp. strain C5 DoxA, a cytochrome P-450 catalyzing multiple steps in doxorubicin biosynthesisDoxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.ABC transporters: bacterial exportersStructural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteriaStructure, function, and evolution of bacterial ATP-binding cassette systemsCloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamineCloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesisStructural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulatorsCrystal Structures of Two Transcriptional Regulators from Bacillus cereus Define the Conserved Structural Features of a PadR SubfamilyThe Sge1 protein of Saccharomyces cerevisiae is a membrane-associated multidrug transporter.Molecular properties of bacterial multidrug transportersMembrane topology of the DrrB protein of the doxorubicin transporter of Streptomyces peucetiusThe tagGH operon of Bacillus subtilis 168 encodes a two-component ABC transporter involved in the metabolism of two wall teichoic acidsRole of nodl and nodJ in lipo-chitooligosaccharide secretion in Azorhizobium caulinodans and Escherichia coliMolecular cloning and characterization of the aklavinone 11-hydroxylase gene of Streptomyces peucetius subsp. caesius ATCC 27952The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesisOverexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosisOrigins and evolution of antibiotic resistanceIdentification of genetic determinants for the hemolytic activity of Streptococcus agalactiae by ISS1 transpositionMolecular cloning and characterization of an ABC multidrug efflux pump, VcaM, in Non-O1 Vibrio choleraeAn ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57.Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimuriumA new subfamily of bacterial ABC-type transport systems catalyzing export of drugs and carbohydrates.The extreme C terminus of the ABC protein DrrA contains unique motifs involved in function and assembly of the DrrAB complexMolecular cloning and functional characterization of an ATP-binding cassette transporter OtrC from Streptomyces rimosus.Compilation and analysis of DNA sequences associated with apparent streptomycete promoters.Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin.Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates.Characterization of a novel domain 'GATE' in the ABC protein DrrA and its role in drug efflux by the DrrAB complexThe Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and productionThe DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis.P-glycoprotein structure and evolutionary homologies.Role of mycobacterial efflux transporters in drug resistance: an unresolved question.A hydroxylase-like gene product contributes to synthesis of a polyketide spore pigment in Streptomyces halstedii.Streptomyces antibioticus contains at least three oleandomycin-resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily.The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development.Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.The role of ATP-binding cassette transporters in bacterial pathogenicity.Regulation of daunorubicin biosynthesis in Streptomyces peucetius - feed forward and feedback transcriptional control.
P2860
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P2860
A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A bacterial analog of the mdr ...... daunorubicin and doxorubicin.
@en
A bacterial analog of the mdr ...... daunorubicin and doxorubicin.
@nl
type
label
A bacterial analog of the mdr ...... daunorubicin and doxorubicin.
@en
A bacterial analog of the mdr ...... daunorubicin and doxorubicin.
@nl
prefLabel
A bacterial analog of the mdr ...... daunorubicin and doxorubicin.
@en
A bacterial analog of the mdr ...... daunorubicin and doxorubicin.
@nl
P2860
P356
P1476
A bacterial analog of the mdr ...... daunorubicin and doxorubicin.
@en
P2093
C R Hutchinson
P G Guilfoile
P2860
P304
P356
10.1073/PNAS.88.19.8553
P407
P577
1991-10-01T00:00:00Z