NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease. - Wikidata - awgldk - TriplyDB

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.

http://www.wikidata.org/entity/Q37599556

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Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia.The Biology and Targeting of FLT3 in Pediatric Leukemia.Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.FLT3 dancing on the stem cell.Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.Knock-in of the R394W mutation causes MDS and cooperates with to drive aggressive myeloid neoplasms in mice

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NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.

http://www.wikidata.org/entity/Q37599556

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 29 October 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

NPMc+ cooperates with Flt3/ITD ...... recapitulating human disease.

@en

NPMc+ cooperates with Flt3/ITD ...... recapitulating human disease.

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type

label

NPMc+ cooperates with Flt3/ITD ...... recapitulating human disease.

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NPMc+ cooperates with Flt3/ITD ...... recapitulating human disease.

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prefLabel

NPMc+ cooperates with Flt3/ITD ...... recapitulating human disease.

@en

NPMc+ cooperates with Flt3/ITD ...... recapitulating human disease.

@nl

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J.EXPHEM.2013.10.005

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Experimental Hematology

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NPMc+ cooperates with Flt3/ITD ...... recapitulating human disease.

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Amy S Duffield

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Colleen Annesley

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Daniel Magoon

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David Huso

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Donald Small

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Emily McIntyre

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Markus Reschke

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Patrick Brown

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Sarah Greenblatt

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P2860

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells

Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells

The role of FLT3 in haematopoietic malignancies

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations.

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.

Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

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10.1016/J.EXPHEM.2013.10.005

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John G Clohessy

Pier Paolo Pandolfi

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2013-10-29T00:00:00Z

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