Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer.
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Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systemsComposition and evolution of the vertebrate and mammalian selenoproteomesTherapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic diseaseSelenium cytotoxicity in cancerCrystal structure of the human thioredoxin reductase-thioredoxin complexThioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signalingMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseSodium selenide toxicity is mediated by O2-dependent DNA breaksROS signaling by NOX4 drives fibroblast-to-myofibroblast differentiation in the diseased prostatic stromaA whole-genome SNP association study of NCI60 cell line panel indicates a role of Ca2+ signaling in selenium resistanceSelenophosphate synthetase 1 (SPS1) is required for the development and selenium homeostasis of central nervous system in chicken (Gallus gallus).Selenoproteins: molecular pathways and physiological roles.Prenatal expression of thioredoxin reductase 1 (TRXR1) and microsomal glutathione transferase 1 (MGST1) in humans.Lower serum levels of selenium, copper, and zinc are related to neuromotor impairments in children with konzo.The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2DNeutralization by metal ions of the toxicity of sodium selenideAlteration of thioredoxin reductase 1 levels in elucidating cancer etiology.Selenite cataracts: activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protectionSelenoglycoproteins attenuate adhesion of tumor cells to the brain microvascular endothelium via a process involving NF-κB activation.p53, oxidative stress, and agingThe potential role of thioredoxin 1 and CD30 systems as multiple pathway targets and biomarkers in tumor therapy.Susceptibility of the antioxidant selenoenyzmes thioredoxin reductase and glutathione peroxidase to alkylation-mediated inhibition by anticancer acylfulvenesRedox-active selenium compounds--from toxicity and cell death to cancer treatmentReduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years: Follow-Up Results of a Prospective Randomized Double-Blind Placebo-Controlled Trial in Elderly CitizensSerum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New ZealandSelenium Digestibility and Bioactivity in Dogs: What the Can Can, the Kibble Can't.Selenium in the prevention of human cancers.Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules.Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanismThioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stressSelenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells.Selenium compounds, apoptosis and other types of cell death: an overview for cancer therapy.Selenium and selenoprotein function in brain disorders.Redox signaling as a therapeutic target to inhibit myofibroblast activation in degenerative fibrotic diseaseThioredoxin reductase and its inhibitors.Biological activity of selenium: Revisited.Protective Role of Selenium Compounds on the Proliferation, Apoptosis, and Angiogenesis of a Canine Breast Cancer Cell Line.Selenium induces a multi-targeted cell death process in addition to ROS formation.
P2860
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P2860
Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Selenium and the selenoprotein ...... ent and diagnostics of cancer.
@en
Selenium and the selenoprotein ...... ent and diagnostics of cancer.
@nl
type
label
Selenium and the selenoprotein ...... ent and diagnostics of cancer.
@en
Selenium and the selenoprotein ...... ent and diagnostics of cancer.
@nl
prefLabel
Selenium and the selenoprotein ...... ent and diagnostics of cancer.
@en
Selenium and the selenoprotein ...... ent and diagnostics of cancer.
@nl
P2093
P356
P1476
Selenium and the selenoprotein ...... ment and diagnostics of cancer
@en
P2093
Anna-Klara Rundlöf
Markus Selenius
Mikael Björnstedt
P304
P356
10.1089/ARS.2009.2884
P577
2010-04-01T00:00:00Z