Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation.
about
Hsp90 Inhibitors for the Treatment of Chronic Myeloid LeukemiaInhibition of 19S proteasome-associated deubiquitinases by metal-containing compoundsA novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases.Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibitionClinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growthAnti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanismsGambogic Acid lysinate induces apoptosis in breast cancer mcf-7 cells by increasing reactive oxygen species.Novel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cellsGambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cellsInhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway.Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo.Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibitionCombination of gambogic acid with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP expression.Y-632 inhibits heat shock protein 90 (Hsp90) function by disrupting the interaction between Hsp90 and Hsp70/Hsp90 organizing protein, and exerts antitumor activity in vitro and in vivoAurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms.Cantharidin Overcomes Imatinib Resistance by Depleting BCR-ABL in Chronic Myeloid Leukemia.Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity.Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy.Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases.Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor.Natural products against hematological malignancies and identification of their targets.Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment.Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro.Molecular targets of gambogic acid in cancer: recent trends and advancements.Gambogic acid induces death of K562 cells through autophagy and apoptosis mechanisms.Gambogic Acid and Its Role in Chronic Diseases.Garcinol and Its Role in Chronic Diseases.Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation.Piperlongumine reverses doxorubicin resistance through the PI3K/Akt signaling pathway in K562/A02 human leukemia cells.A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers.A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy.Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents.Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase.Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing.Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination.Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.Emerging small molecule approaches to enhance the antimyeloma benefit of proteasome inhibitors.Folate-decorated arginine-based poly(ester urea urethane) nanoparticles as carriers for gambogic acid and effect on cancer cells.
P2860
Q26771790-1CB71A74-C382-46AA-B09D-5A9FE932E3B1Q28082497-15EFB469-A4B5-466C-B5D2-1CAA7C049AE3Q33729793-1B88165F-D2A5-4B1A-B436-C57337919F57Q33801982-4CCDBF0E-1BDC-4B93-B574-FE5724C73215Q34221890-4A15C9F5-C21A-4A47-A3CA-706818E36623Q34619261-19575FBC-40C3-41AD-9D65-EA65D00306A7Q35240718-6D820804-E5DC-4B7A-86AC-7F3F07BC763DQ35615675-96552942-89E7-42E8-BD6D-11FCEBB4008FQ36140567-89AD3C0B-B25D-4111-B303-7100C5D05F95Q36331012-AEDB89D9-D946-466D-A04A-030484FE201AQ36591288-49E991E7-3CD6-40C7-A265-14779C332BC8Q36771950-F7C93F47-5E85-4810-A5A6-53D2CAC4969CQ36972631-FD313911-6A75-44DE-8699-85075CCFE5AAQ36982278-FFA0FA33-FE7E-44A7-8BFB-5221C2D30FA3Q37142416-128F522F-03A0-4177-A961-BB25631862B5Q37399824-86C5D534-6E21-40B3-9010-F43B7B0C1B54Q37440054-AF5AAD49-2518-49EC-BF29-051BF450EB9DQ37575771-707AF3E8-2DB0-4B6F-8846-1679E1289E42Q37593936-9A6C2DF2-BBEF-4C8D-B2B5-AB64320978C6Q37619364-CAFD7B1A-369E-4192-97F9-85B836285977Q37706728-4F5FEB53-5BB5-405A-9768-8F0DC666D7B9Q37745139-D5183DE2-2D52-4C9A-BFD9-689B8209FAA5Q38632963-3AF46C14-3798-42E9-BA7F-856CC4B17AB5Q38712865-914CFB26-3AE9-4D45-BE45-A686060F4244Q38866753-DD284D1E-C8D7-4D99-A827-62AA75CFC30DQ38905684-33B0BD50-7108-4611-8515-512246F88B02Q38907835-A0E0A35A-F8D6-42AA-8AA1-B099628C6A24Q38965229-4E1D172B-BEBF-46C1-8C79-89B4192C179DQ38965241-940154E2-A32D-441A-804C-1D7C26F8BCD9Q41335233-9FA46B38-9A4B-4D99-AC4C-49ECD5F9FF14Q42167869-79C70446-B06E-4A20-A060-1683A415F774Q42362660-3EBE134E-7A1E-4002-A8E9-A1905199D492Q43226621-B4F8031B-8893-4F9F-AF89-DD2D2EAD52DDQ47098444-D910834F-EAE6-4221-A5B5-AC395F2D4734Q47446573-252F677C-D56F-46A2-9C02-EE7E4F1AC6BDQ47631097-B4B491DE-5DEA-4F76-B0F8-1FE8C668E5ADQ48529877-E8DC9DEC-818E-4CB7-9CB3-F62DEC5F9034Q49887894-2034CE3C-7549-4D4A-B512-9955BCCE8F5BQ50026815-30879D21-947F-4314-90B6-9E15A5834A87Q51116566-CDB8E823-1349-43DA-A679-2D12C2AEA6D6
P2860
Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 December 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Gambogic acid induces apoptosi ...... endent Bcr-Abl downregulation.
@en
Gambogic acid induces apoptosi ...... endent Bcr-Abl downregulation.
@nl
type
label
Gambogic acid induces apoptosi ...... endent Bcr-Abl downregulation.
@en
Gambogic acid induces apoptosi ...... endent Bcr-Abl downregulation.
@nl
prefLabel
Gambogic acid induces apoptosi ...... endent Bcr-Abl downregulation.
@en
Gambogic acid induces apoptosi ...... endent Bcr-Abl downregulation.
@nl
P2093
P2860
P1476
Gambogic acid induces apoptosi ...... endent Bcr-Abl downregulation.
@en
P2093
Chong Zhao
Hongbiao Huang
Jinbao Liu
Ningning Liu
Q Ping Dou
Shouting Liu
Shunqing Wang
Siyan Liao
P2860
P304
P356
10.1158/1078-0432.CCR-13-1063
P407
P577
2013-12-12T00:00:00Z