HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. - Wikidata - awgldk - TriplyDB

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

http://www.wikidata.org/entity/Q37612752

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The E3 ubiquitin ligase Hace1 is required for early embryonic development in Xenopus laevis.E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration NKX6.3 Regulates Reactive Oxygen Species Production by Suppressing NF-kB and DNMT1 Activities in Gastric Epithelial Cells.Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients.Metformin increases degradation of phospholamban via autophagy in cardiomyocytes Toxicogenomics of Phenylhydrazine Induced Hematotoxicity and its Attenuation by Plumbagin from Plumbago zeylanica.HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex.The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review.Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.Impact of Mediterranean diet on metabolic syndrome, cancer and longevity.Inhibition of cancer antioxidant defense by natural compounds.Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Spin Trapping: A Review for the Study of Obesity Related Oxidative Stress and Na+/K+-ATPase.Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?Chronic Progressive Neurodegeneration in a Transgenic Mouse Model of Prion Disease.Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats.Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells.Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities.

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HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

http://www.wikidata.org/entity/Q37612752

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 February 2014

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

HACE1 reduces oxidative stress ...... y promoting the NRF2 response.

@en

HACE1 reduces oxidative stress ...... y promoting the NRF2 response.

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type

label

HACE1 reduces oxidative stress ...... y promoting the NRF2 response.

@en

HACE1 reduces oxidative stress ...... y promoting the NRF2 response.

@nl

prefLabel

HACE1 reduces oxidative stress ...... y promoting the NRF2 response.

@en

HACE1 reduces oxidative stress ...... y promoting the NRF2 response.

@nl

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PNAS.1314421111

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Proceedings of the National Academy of Sciences of the United States of America

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HACE1 reduces oxidative stress ...... by promoting the NRF2 response

@en

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Adi Barokas

http://www.w3.org/2001/XMLSchema#string

Barak Rotblat

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Brian Kwok

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Christopher J Carnie

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Dieter Fink

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Gabriel Leprivier

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Gerry Melino

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Jason D Galpin

http://www.w3.org/2001/XMLSchema#string

Joan Mathers

http://www.w3.org/2001/XMLSchema#string

Liheng Li

http://www.w3.org/2001/XMLSchema#string

P2860

The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

Role of cerebral cortex in the neuropathology of Huntington's disease

Ageing as a risk factor for disease

Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

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3032-3037

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scholarly article

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10.1073/PNAS.1314421111

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8

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111

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Josef M Penninger

Amber L Southwell

Christopher A Ahern

Michael R. Hayden

Dagmar E Ehrnhoefer

Syam Prakash Somasekharan

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2014-02-10T00:00:00Z

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260154653

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24516159

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3939919

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