A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity
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Colistin in Pig Production: Chemistry, Mechanism of Antibacterial Action, Microbial Resistance Emergence, and One Health PerspectivesProbing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteriaResistance to Colistin in Klebsiella Pneumoniae: A 4.0 Strain?Antibacterial effect of crude extract and metabolites of Phytolacca americana on pathogens responsible for periodontal inflammatory diseases and dental cariesPolymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model.The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets.Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens.Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii.Colistin: still a lifesaver for the 21st century?A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicityThe mechanism of catalysis by type-II NADH:quinone oxidoreductases.Rediscovering the octapeptins.Recent advances and perspectives in the design and development of polymyxins.Clinical Pharmacokinetics and Pharmacodynamics of Colistin.Interplay between Colistin Resistance, Virulence and Fitness in Acinetobacter baumannii.Colistin causes profound morphological alteration but minimal cytoplasmic membrane perforation in populations of Escherichia coli and Pseudomonas aeruginosa.Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae.Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors.Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets.
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A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A secondary mode of action of ...... uinone oxidoreductase activity
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A secondary mode of action of ...... inone oxidoreductase activity.
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A secondary mode of action of ...... uinone oxidoreductase activity
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A secondary mode of action of ...... inone oxidoreductase activity.
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A secondary mode of action of ...... uinone oxidoreductase activity
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A secondary mode of action of ...... inone oxidoreductase activity.
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A secondary mode of action of ...... uinone oxidoreductase activity
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Jesmin Akter
Kade D Roberts
Roger L Nation
Sivashangarie Sivanesan
Zakuan Z Deris
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10.1038/JA.2013.111
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2013-10-30T00:00:00Z