The Hsp90 chaperone machinery: from structure to drug development.
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Hsp90: A New Player in DNA Repair?Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studiesDistinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channelsDynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1Natural iminosugar (+)-lentiginosine inhibits ATPase and chaperone activity of hsp90Hsp90 inhibitor SY-016 induces G2/M arrest and apoptosis in paclitaxel-resistant human ovarian cancer cellsPhase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors.HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation.Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.Aniline-induced nitrosative stress in rat spleen: proteomic identification of nitrated proteins.Expression and purification of Src-family kinases for solution NMR studies.Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression.Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.Gene expression, metabolic regulation and stress tolerance during diapause.Molecular chaperones as rational drug targets for Parkinson's disease therapeutics.Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.The role of heat shock protein 90 in modulating ischemia-reperfusion injury in the kidney.Building Cell Selectivity into CPP-Mediated Strategies.Molecular characterization of interdigitating dendritic cell sarcoma.Expression of hsp90 mediates cytoprotective effects in the gastrodermis of planarians.Trypanosome prereplication machinery: a potential new target for an old problem.Characterization of the constitutive pig ovary heat shock chaperone machinery and its response to acute thermal stress or to seasonal variations.Proteasome inhibition-induced downregulation of Akt/GSK-3β pathway contributes to abnormality of tau in hippocampal slice.Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex
P2860
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P2860
The Hsp90 chaperone machinery: from structure to drug development.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The Hsp90 chaperone machinery: from structure to drug development.
@en
The Hsp90 chaperone machinery: from structure to drug development.
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type
label
The Hsp90 chaperone machinery: from structure to drug development.
@en
The Hsp90 chaperone machinery: from structure to drug development.
@nl
prefLabel
The Hsp90 chaperone machinery: from structure to drug development.
@en
The Hsp90 chaperone machinery: from structure to drug development.
@nl
P1433
P1476
The Hsp90 chaperone machinery: from structure to drug development.
@en
P2093
Ji-Sook Hahn
P304
P356
10.5483/BMBREP.2009.42.10.623
P577
2009-10-01T00:00:00Z