Microfluidic assay of hemophilic blood clotting: distinct deficits in platelet and fibrin deposition at low factor levels.
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In microfluidico: Recreating in vivo hemodynamics using miniaturized devicesFXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flowMicrofluidic assessment of functional culture-derived platelets in human thrombi under flow.Microfluidic whole blood testing of platelet response to pharmacological agents.Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technologyViscoelastic measurements of platelet function, not fibrinogen function, predicts sensitivity to tissue-type plasminogen activator in trauma patients.Systems Analysis of Thrombus Formation.Microfluidic technology as an emerging clinical tool to evaluate thrombosis and hemostasis.Transport physics and biorheology in the setting of hemostasis and thrombosis.Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders.Application of microfluidic devices in studies of thrombosis and hemostasis.Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow.Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay.Dynamics of Thrombin Generation and Flux from Clots during Whole Human Blood Flow over Collagen/Tissue Factor Surfaces.Recombinant factor VIIa addition to haemophilic blood perfused over collagen/tissue factor can sufficiently bypass the factor IXa/VIIIa defect to rescue fibrin generation.Clinical and laboratory phenotype variability in type 2M von Willebrand disease.Recombinant factor VIIa enhances platelet deposition from flowing haemophilic blood but requires the contact pathway to promote fibrin deposition.Use of microfluidics to assess the platelet-based control of coagulation.
P2860
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P2860
Microfluidic assay of hemophilic blood clotting: distinct deficits in platelet and fibrin deposition at low factor levels.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Microfluidic assay of hemophil ...... position at low factor levels.
@en
Microfluidic assay of hemophil ...... position at low factor levels.
@nl
type
label
Microfluidic assay of hemophil ...... position at low factor levels.
@en
Microfluidic assay of hemophil ...... position at low factor levels.
@nl
prefLabel
Microfluidic assay of hemophil ...... position at low factor levels.
@en
Microfluidic assay of hemophil ...... position at low factor levels.
@nl
P2093
P2860
P356
P1476
Microfluidic assay of hemophil ...... position at low factor levels.
@en
P2093
P2860
P304
P356
10.1111/JTH.12457
P577
2014-02-01T00:00:00Z