Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
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Colorectal cancer models for novel drug discoveryFluorescence-based endoscopic imaging of Thomsen-Friedenreich antigen to improve early detection of colorectal cancer.Mechanisms underlying 18F-fluorodeoxyglucose accumulation in colorectal cancerCross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.An EGFR targeted PET imaging probe for the detection of colonic adenocarcinomas in the setting of colitisAnimal models and therapeutic molecular targets of cancer: utility and limitations.Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.Rodent intestinal epithelial carcinogenesis: pathology and preclinical models.Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.In vivo genome editing and organoid transplantation models of colorectal cancer and metastasisTranslational value of mouse models in oncology drug development.Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.PKM2 is not required for colon cancer initiated by APC loss.
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Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 February 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Development of a colon cancer ...... drug discovery and validation.
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Development of a colon cancer ...... drug discovery and validation.
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type
label
Development of a colon cancer ...... drug discovery and validation.
@en
Development of a colon cancer ...... drug discovery and validation.
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prefLabel
Development of a colon cancer ...... drug discovery and validation.
@en
Development of a colon cancer ...... drug discovery and validation.
@nl
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P2860
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Development of a colon cancer ...... drug discovery and validation
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P2093
Eric S Martin
Erin M Coffee
Gautam Goel
Julie L C Kan
Kenneth E Hung
Larissa Georgeon Richard
Mark J Sinnamon
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P304
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10.1158/1078-0432.CCR-12-2307
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P577
2013-02-12T00:00:00Z