about
In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cellsGranzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout miceInvolvement of Kallikrein-Related Peptidases in Normal and Pathologic ProcessesCytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activationInterleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in primary immune thrombocytopenia.Proteomic profiling of proteases: tools for granzyme degradomics.Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell massIFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms.Perforin: an important player in immune response.Quantitative Genetics of Food Intake in Drosophila melanogaster.B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo.Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforinThe structure and function of mammalian membrane-attack complex/perforin-like proteins.Viruses and cytotoxic T lymphocytes in type 1 diabetes.Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases.Immunological pathways to β-cell damage in Type 1 diabetes.Targeting the pancreatic β-cell to treat diabetes.Blessing or curse? Proteomics in granzyme research.Islet inflammation in human type 1 diabetes mellitus.The beta-cell in type 1 diabetes: What have we learned from proteomic studies?Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis.Understanding type 1 diabetes through proteomics.Role of genetics in resistance to type 1 diabetes.Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.Long-term outcome of patients with virus-negative chronic myocarditis or inflammatory cardiomyopathy after immunosuppressive therapy.Fas/Fas-Ligand Interaction As a Mechanism of Immune Homeostasis and β-Cell Cytotoxicity: Enforcement Rather Than Neutralization for Treatment of Type 1 Diabetes.Human transcriptome analysis of acute responses to glucose ingestion reveals the role of leukocytes in hyperglycemia-induced inflammation.Human islet cells are killed by BID-independent mechanisms in response to FAS ligand.
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
The role of perforin and granzymes in diabetes.
@en
The role of perforin and granzymes in diabetes.
@nl
type
label
The role of perforin and granzymes in diabetes.
@en
The role of perforin and granzymes in diabetes.
@nl
prefLabel
The role of perforin and granzymes in diabetes.
@en
The role of perforin and granzymes in diabetes.
@nl
P2860
P356
P1476
The role of perforin and granzymes in diabetes
@en
P2093
P2860
P2888
P304
P356
10.1038/CDD.2009.165
P577
2009-11-20T00:00:00Z