AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.
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Regulation of the phosphatase PP2B by protein-protein interactionsPituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large-conductance Ca(2+)-activated (BK) and ATP-sensitive (K ATP) K (+) channels.Protein kinase A catalytic subunit isoform PRKACA; History, function and physiologyWestern blot analysis of BK channel β1-subunit expression should be interpreted cautiously when using commercially available antibodies.Carvedilol reverses cardiac insufficiency in AKAP5 knockout mice by normalizing the activities of calcineurin and CaMKII.Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetesEffects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency.A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors.Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin PolymerizationBK channel β1-subunit deficiency exacerbates vascular fibrosis and remodelling but does not promote hypertension in high-fat fed obesity in mice.AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve.Abnormal Rho-associated kinase activity contributes to the dysfunctional myogenic response of cerebral arteries in type 2 diabetes.Lack of direct effect of adiponectin on vascular smooth muscle cell BKCa channels or Ca2+ signaling in the regulation of small artery pressure-induced constriction.Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia.Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes.Vascular hyperpolarization in human physiology and cardiovascular risk conditions and disease.Calcium Channels in Vascular Smooth Muscle.Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth.Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Activation of PERK branch of ER stress mediates homocysteine-induced BKCa channel dysfunction in coronary artery via FoxO3a-dependent regulation of atrogin-1.Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice.Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes.Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivityLoss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.Myocardial Po2 does not limit aerobic metabolism in the postischemic heart.Dynamic Regulation of the Subunit Composition of BK Channels in Smooth Muscle.Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders.Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats.Salidroside improved cerebrovascular vasodilation in streptozotocin-induced diabetic rats through restoring the function of BKCa channel in smooth muscle cells.Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling.
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AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
AKAP150 contributes to enhance ...... lycemia and diabetes mellitus.
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AKAP150 contributes to enhance ...... lycemia and diabetes mellitus.
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type
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AKAP150 contributes to enhance ...... lycemia and diabetes mellitus.
@en
AKAP150 contributes to enhance ...... lycemia and diabetes mellitus.
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AKAP150 contributes to enhance ...... lycemia and diabetes mellitus.
@en
AKAP150 contributes to enhance ...... lycemia and diabetes mellitus.
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P2093
P2860
P50
P1433
P1476
AKAP150 contributes to enhance ...... glycemia and diabetes mellitus
@en
P2093
C Blake Nichols
Chao-Yin Chen
John D Scott
Jose L Puglisi
Leighton T Izu
Madeline Nieves-Cintrón
Manuel F Navedo
Matthew A Nystoriak
Patrick J Nygren
Simon A Hinke
P2860
P304
P356
10.1161/CIRCRESAHA.114.302168
P577
2013-12-09T00:00:00Z