The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory
about
Kinesin-4 KIF21B is a potent microtubule pausing factor.Dynein efficiently navigates the dendritic cytoskeleton to drive the retrograde trafficking of BDNF/TrkB signaling endosomes.Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B.Overexpression of cypin alters dendrite morphology, single neuron activity, and network properties via distinct mechanisms.Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1-42 synaptotoxicity.Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.Combined acupuncture and HuangDiSan treatment affects behavior and synaptophysin levels in the hippocampus of senescence-accelerated mouse prone 8 after neural stem cell transplantation.NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization.
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P2860
The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 April 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The Kinesin KIF21B Regulates M ...... ction, and Learning and Memory
@en
The Kinesin KIF21B Regulates M ...... tion, and Learning and Memory.
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type
label
The Kinesin KIF21B Regulates M ...... ction, and Learning and Memory
@en
The Kinesin KIF21B Regulates M ...... tion, and Learning and Memory.
@nl
prefLabel
The Kinesin KIF21B Regulates M ...... ction, and Learning and Memory
@en
The Kinesin KIF21B Regulates M ...... tion, and Learning and Memory.
@nl
P2093
P2860
P1433
P1476
The Kinesin KIF21B Regulates M ...... ction, and Learning and Memory
@en
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Amy E Ghiretti
Dorthe Labonté
Edda Thies
Erika L F Holzbaur
Francesca Xompero
Irm Hermans-Borgmeyer
Jürgen R Schwarz
Kira V Gromova
Mary Muhia
Matthias Kneussel
P2860
P304
P356
10.1016/J.CELREP.2016.03.086
P577
2016-04-21T00:00:00Z