Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth.
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mTOR inhibitors in advanced renal cell carcinomaTargeting the mTOR kinase domain: the second generation of mTOR inhibitorsA unifying theory for general multigenic heterosis: energy efficiency, protein metabolism, and implications for molecular breedingThe PI3K/Akt/mTOR pathway in ovarian cancer: therapeutic opportunities and challengesmTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesiaAutophagy in thyroid cancer: present knowledge and future perspectivesThe PIM kinases in hematological cancersAkt1 enhances CA916798 expression through mTOR pathwayTemsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expressionVitamin E succinate induces apoptosis via the PI3K/AKT signaling pathways in EC109 esophageal cancer cellsPhase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcomaDetection of WIPI1 mRNA as an indicator of autophagosome formationTuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation.Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells.Expression of metabolic, tissue remodeling, oxidative stress, and inflammatory pathways in mammary tissue during involution in lactating dairy cowsExtensive gene-specific translational reprogramming in a model of B cell differentiation and Abl-dependent transformationRapamycin sensitizes T-ALL cells to dexamethasone-induced apoptosis.The Pim protein kinases regulate energy metabolism and cell growthThe dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphomaα-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways.Loss of primary cilia upregulates renal hypertrophic signaling and promotes cystogenesis.Cellular effects of everolimus and sirolimus on podocytes.MLN0128, an ATP-competitive mTOR kinase inhibitor with potent in vitro and in vivo antitumor activity, as potential therapy for bone and soft-tissue sarcoma.Sirolimus demonstrates activity in the primary therapy of acute graft-versus-host disease without systemic glucocorticoids.Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells.A critical role for the mTORC2 pathway in lung fibrosis.Molecular mechanism of local drug delivery with Paclitaxel-eluting membranes in biliary and pancreatic cancer: new application for an old drugTargeting the phosphatidylinositol 3-kinase signaling pathway in breast cancer.mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells.Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signalingNon-coding rRNA-mediated preferential killing in cancer cells is enhanced by suppression of autophagy in non-transformed counterpart.Leucine Promotes Proliferation and Differentiation of Primary Preterm Rat Satellite Cells in Part through mTORC1 Signaling Pathway.Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1pSPARC Controls Melanoma Cell Plasticity through Rac1.DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesisTumor cell metabolism: an integral view.Metformin: multi-faceted protection against cancer.Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study.Cellular metabolism and disease: what do metabolic outliers teach us?Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling
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Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mammalian target of rapamycin: ...... normal and cancer cell growth.
@en
Mammalian target of rapamycin: ...... normal and cancer cell growth.
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type
label
Mammalian target of rapamycin: ...... normal and cancer cell growth.
@en
Mammalian target of rapamycin: ...... normal and cancer cell growth.
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prefLabel
Mammalian target of rapamycin: ...... normal and cancer cell growth.
@en
Mammalian target of rapamycin: ...... normal and cancer cell growth.
@nl
P2093
P1433
P1476
Mammalian target of rapamycin: ...... normal and cancer cell growth.
@en
P2093
James J Gibbons
Robert T Abraham
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P356
10.1053/J.SEMINONCOL.2009.10.011
P478
36 Suppl 3
P577
2009-12-01T00:00:00Z