Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease. - Wikidata - awgldk - TriplyDB

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.

http://www.wikidata.org/entity/Q37651883

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Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation.The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease.Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response.Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response.Rethinking HSF1 in Stress, Development, and Organismal Health.Regulation of heat shock transcription factors and their roles in physiology and disease.Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes.The heat-shock, or HSF1-mediated proteotoxic stress, response in cancer: from proteomic stability to oncogenesis.Physiological functions of FBW7 in cancer and metabolism.Quantification of Hsp90 availability reveals differential coupling to the heat shock response

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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.

http://www.wikidata.org/entity/Q37651883

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 February 2017

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Abnormal degradation of the ne ...... HSF1 in Huntington's disease.

@en

Abnormal degradation of the ne ...... HSF1 in Huntington's disease.

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type

label

Abnormal degradation of the ne ...... HSF1 in Huntington's disease.

@en

Abnormal degradation of the ne ...... HSF1 in Huntington's disease.

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prefLabel

Abnormal degradation of the ne ...... HSF1 in Huntington's disease.

@en

Abnormal degradation of the ne ...... HSF1 in Huntington's disease.

@nl

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Nature Communications

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Abnormal degradation of the ne ...... HSF1 in Huntington's disease.

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Alejandro Aballay

http://www.w3.org/2001/XMLSchema#string

Alex M Jaeger

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Argenia Doss

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Christopher A Ross

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Daniel W Neef

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Dennis J Thiele

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Donald C Lo

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Eileen T Burchfiel

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Elisa Cabiscol

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Rocio Gomez-Pastor

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Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex

Adapting proteostasis for disease intervention

Regulation of HSF1 function in the heat stress response: implications in aging and disease

Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

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scholarly article

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10.1038/NCOMMS14405

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8

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Spencer U McKinstry

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2017-02-13T00:00:00Z

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1083800149

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28194040

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Huntington disease

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5316841

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