The role of HMGCR alternative splicing in statin efficacy.
about
Differential transcriptional and posttranslational transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients.Exposure to high levels of glucose increases the expression levels of genes involved in cholesterol biosynthesis in rat isletsDysregulation of the mevalonate pathway promotes transformationPrediction of LDL cholesterol response to statin using transcriptomic and genetic variationA novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus.Variants affecting exon skipping contribute to complex traits.Improvement in prediction of coronary heart disease risk over conventional risk factors using SNPs identified in genome-wide association studies.Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits.HDL cholesterol and stroke risk: The Multi-Ethnic Study of Atherosclerosis.Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han ChineseStatin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner.Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia.Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology.The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages.Statin dose in Asians: is pharmacogenetics relevant?
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P2860
The role of HMGCR alternative splicing in statin efficacy.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The role of HMGCR alternative splicing in statin efficacy.
@en
The role of HMGCR alternative splicing in statin efficacy.
@nl
type
label
The role of HMGCR alternative splicing in statin efficacy.
@en
The role of HMGCR alternative splicing in statin efficacy.
@nl
prefLabel
The role of HMGCR alternative splicing in statin efficacy.
@en
The role of HMGCR alternative splicing in statin efficacy.
@nl
P2860
P1476
The role of HMGCR alternative splicing in statin efficacy.
@en
P2093
Marisa Wong Medina
Ronald M Krauss
P2860
P304
P356
10.1016/J.TCM.2009.10.003
P577
2009-07-01T00:00:00Z