Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice
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Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise trainingThe Neuromuscular Junction: Aging at the Crossroad between Nerves and MuscleAgeing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expressionThe role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosisThe lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.Superoxide dismutase 1 loss disturbs intracellular redox signaling, resulting in global age-related pathological changes.Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice.Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxideMuscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions.Effects of chromium-enriched Bacillus subtilis KT260179 supplementation on growth performance, caecal microbiology, tissue chromium level, insulin receptor expression and plasma biochemical profile of mice under heat stress.Redox regulation of muscle adaptations to contractile activity and aging.Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice.Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice.Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype.Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophyLong-term administration of the mitochondria-targeted antioxidant mitoquinone mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle.Skeletal muscle aging: influence of oxidative stress and physical exercise.Revisiting an age-old question regarding oxidative stress.Innervation and neuromuscular control in ageing skeletal muscle.Redox homeostasis and age-related deficits in neuromuscular integrity and function.Role of reactive oxygen species in age-related neuromuscular deficits.Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage.Role of nerve-muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing.Denervated muscle fibers induce mitochondrial peroxide generation in neighboring innervated fibers: Role in muscle aging.Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice.Sporadic amyotrophic lateral sclerosis (SALS) - skeletal muscle response to cerebrospinal fluid from SALS patients in a rat model.Smoke-induced neuromuscular junction degeneration precedes the fibre type shift and atrophy in COPD.Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.Age-related changes in skeletal muscle: changes to life-style as a therapy
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Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Neuron-specific expression of ...... mozygous CuZnSOD-knockout mice
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Neuron-specific expression of ...... ozygous CuZnSOD-knockout mice.
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type
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Neuron-specific expression of ...... mozygous CuZnSOD-knockout mice
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Neuron-specific expression of ...... ozygous CuZnSOD-knockout mice.
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Neuron-specific expression of ...... mozygous CuZnSOD-knockout mice
@en
Neuron-specific expression of ...... ozygous CuZnSOD-knockout mice.
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Neuron-specific expression of ...... mozygous CuZnSOD-knockout mice
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Anne McArdle
Arlan Richardson
Carol S Davis
Giorgos K Sakellariou
Maxim V Ivannikov
Susan V Brooks
Yiqiang Zhang
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P304
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10.1096/FJ.13-240390
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P577
2013-12-30T00:00:00Z