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FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgAThe E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in miceHigh-resolution structures of the IgM Fc domains reveal principles of its hexamer formationKinetic Control in Protein Folding for Light Chain Amyloidosis and the Differential Effects of Somatic MutationsThe structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulinsComparison of internal ribosome entry site (IRES) and Furin-2A (F2A) for monoclonal antibody expression level and quality in CHO cellsIdentification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomesCrystallographic and modelling studies suggest that the SKICH domains from different protein families share a common Ig-like fold but harbour substantial structural variations.The lid domain of Caenorhabditis elegans Hsc70 influences ATP turnover, cofactor binding and protein folding activity.Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chainOligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana.Protein folding in the cell: challenges and progress.Protein Folding Mechanism of the Dimeric AmphiphysinII/Bin1 N-BAR Domain.Lepidopteran cells, an alternative for the production of recombinant antibodies?Enhancing antibody folding and secretion by tailoring the Saccharomyces cerevisiae endoplasmic reticulum.Identifying bottlenecks in transient and stable production of recombinant monoclonal-antibody sequence variants in Chinese hamster ovary cellsDimerization-dependent folding underlies assembly control of the clonotypic αβT cell receptor chainsHost Anti-antibody Responses Following Adeno-associated Virus-mediated Delivery of Antibodies Against HIV and SIV in Rhesus MonkeysEditing of mouse and human immunoglobulin genes by CRISPR-Cas9 system.Improved antibody production in Chinese hamster ovary cells by ATF4 overexpressionEfficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.Systemic amyloidoses.Proteins improving recombinant antibody production in mammalian cells.Following nature's roadmap: folding factors from plasma cells led to improvements in antibody secretion in S. cerevisiae.Model-directed engineering of "difficult-to-express" monoclonal antibody production by Chinese hamster ovary cells.Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies.Production and characterization of a CD25-specific scFv-Fc antibody secreted from Pichia pastoris.Overexpression of CHOP alone and in combination with chaperones is effective in improving antibody production in mammalian cells.Engineering toward a bacterial "endoplasmic reticulum" for the rapid expression of immunoglobulin proteins.Two immunoglobulin tandem proteins with a linking β-strand reveal unexpected differences in cooperativity and folding pathways.Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system.Biophysical analysis of the effect of chemical modification by 4-oxononenal on the structure, stability, and function of binding immunoglobulin protein (BiP).IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design.Cell-free synthesis of functional antibodies using a coupled in vitro transcription-translation system based on CHO cell lysatesTriFabs--Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery.Systematic screening of soluble expression of antibody fragments in the cytoplasm of E. coli.Hypoxia influences protein transport and epigenetic repression of CHO cell cultures in shake flasks.The extracellular membrane-proximal domain of membrane-bound IgE restricts B cell activation by limiting B cell antigen receptor surface expression.Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients?Structure and energetic basis of overrepresented λ light chain in systemic light chain amyloidosis patients.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
How antibodies fold
@en
How antibodies fold.
@nl
type
label
How antibodies fold
@en
How antibodies fold.
@nl
prefLabel
How antibodies fold
@en
How antibodies fold.
@nl
P2093
P2860
P1476
How antibodies fold
@en
P2093
Johannes Buchner
Linda M Hendershot
Matthias J Feige
P2860
P304
P356
10.1016/J.TIBS.2009.11.005
P577
2009-12-21T00:00:00Z