IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
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Metabolism Is Central to Tolerogenic Dendritic Cell FunctionAre Microglial Cells the Regulators of Lymphocyte Responses in the CNS?Regulatory T cells in autoimmune neuroinflammationNK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis.Immunomodulatory activity of interferon-betaMultifaceted interactions between adaptive immunity and the central nervous system.IL-27 and the generation of CD8+ T-cell responses to peptide vaccines.Peripherally Induced Regulatory T Cells: Recruited Protectors of the Central Nervous System against Autoimmune Neuroinflammation.Dynamic regulation of serum aryl hydrocarbon receptor agonists in MSIL-21 induces IL-22 production in CD4+ T cells.Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.Orchestration of transplantation tolerance by regulatory dendritic cell therapy or in-situ targeting of dendritic cells.IL-27-induced modulation of autoimmunity and its therapeutic potential.Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.Role and therapeutic value of dendritic cells in central nervous system autoimmunity.The Yin and Yang aspects of IL-27 in induction of cancer-specific T-cell responses and immunotherapy.Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation.Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation.NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis.Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral PersistencePeripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression.ESX-1 exploits type I IFN-signalling to promote a regulatory macrophage phenotype refractory to IFNγ-mediated autophagy and growth restriction of intracellular mycobacteria.Mechanisms of immunological tolerance in central nervous system inflammatory demyelination.Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members.Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence.CD73 is expressed by inflammatory Th17 cells in experimental autoimmune encephalomyelitis but does not limit differentiation or pathogenesis.Achieving Tolerance with Perforin-Secreting Dendritic Cells.IL-27 induces the expression of IDO and PD-L1 in human cancer cells.Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System InvolvementGalectin-1 is essential for the induction of MOG35-55 -based intravenous tolerance in experimental autoimmune encephalomyelitis.Cytokine regulation of immune toleranceNeural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS AutoimmunityAHR Activation Is Protective against Colitis Driven by T Cells in Humanized MiceThe plasticity of human Treg and Th17 cells and its role in autoimmunity.Estrogen Receptor-Dependent Regulation of Dendritic Cell Development and Function.Thymic DCs derived IL-27 regulates the final maturation of CD4(+) SP thymocytes.Transcriptomic network support distinct roles of classical and non-classical monocytes in human.
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IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
IL-27 acts on DCs to suppress ...... mmunoregulatory molecule CD39.
@en
IL-27 acts on DCs to suppress ...... mmunoregulatory molecule CD39.
@nl
type
label
IL-27 acts on DCs to suppress ...... mmunoregulatory molecule CD39.
@en
IL-27 acts on DCs to suppress ...... mmunoregulatory molecule CD39.
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prefLabel
IL-27 acts on DCs to suppress ...... mmunoregulatory molecule CD39.
@en
IL-27 acts on DCs to suppress ...... mmunoregulatory molecule CD39.
@nl
P2093
P2860
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P1476
IL-27 acts on DCs to suppress ...... mmunoregulatory molecule CD39.
@en
P2093
Bonny Patel
Evan J Burns
Francisco J Quintana
Ivan D Mascanfroni
Rotem Ben-Hamo
Silvio M Vieira
Simon C Robson
P2860
P2888
P304
P356
10.1038/NI.2695
P407
P577
2013-09-01T00:00:00Z
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P6179
1005433890