The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo.
about
PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features.The frequency of granulocytes with spontaneous somatic mutations: a wide distribution in a normal human populationHuman erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.Leukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia.Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.The ecology of cancer from an evolutionary game theory perspective.Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.Development of an in vitro PIG-A gene mutation assay in human cells.The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells.Genetic instability in lymphoblastoid cell lines expressing biallelic and monoallelic variants in the human MUTYH gene.Loss of MUTYH function in human cells leads to accumulation of oxidative damage and genetic instability.In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation.The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.A population study using the human erythrocyte PIG-A assay.Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene productSomatic mutations in cancer development.Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.Correction: Somatic mutations in cancer development.Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea.Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.
P2860
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P2860
The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 December 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The use of PIG-A as a sentinel ...... d of mutagenic agents in vivo.
@en
The use of PIG-A as a sentinel ...... d of mutagenic agents in vivo.
@nl
type
label
The use of PIG-A as a sentinel ...... d of mutagenic agents in vivo.
@en
The use of PIG-A as a sentinel ...... d of mutagenic agents in vivo.
@nl
prefLabel
The use of PIG-A as a sentinel ...... d of mutagenic agents in vivo.
@en
The use of PIG-A as a sentinel ...... d of mutagenic agents in vivo.
@nl
P2093
P1433
P1476
The use of PIG-A as a sentinel ...... d of mutagenic agents in vivo.
@en
P2093
Benedetta Peruzzi
David J Araten
Rosario Notaro
P356
10.1016/J.MRREV.2009.12.004
P407
P577
2009-12-24T00:00:00Z