The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease. - Wikidata - awgldk - TriplyDB

The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.

The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.

http://www.wikidata.org/entity/Q37663855

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The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Differential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease.Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways

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The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.

http://www.wikidata.org/entity/Q37663855

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The de-ubiquitinating enzyme a ...... e model of Huntington disease.

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The de-ubiquitinating enzyme a ...... e model of Huntington disease.

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The de-ubiquitinating enzyme a ...... e model of Huntington disease.

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The de-ubiquitinating enzyme a ...... e model of Huntington disease.

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The de-ubiquitinating enzyme a ...... e model of Huntington disease.

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The de-ubiquitinating enzyme a ...... e model of Huntington disease.

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Journal of Huntington's Disease

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The de-ubiquitinating enzyme a ...... e model of Huntington disease.

@en

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Bo Wang

http://www.w3.org/2001/XMLSchema#string

Henry L Paulson

http://www.w3.org/2001/XMLSchema#string

Li Zeng

http://www.w3.org/2001/XMLSchema#string

Roger L Albin

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Sara J Tallaksen-Greene

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P2860

Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death

Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities

Molecular chaperones in the cytosol: from nascent chain to folded protein

Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin

Proteotoxic stress increases nuclear localization of ataxin-3

Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation

Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease

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201-215

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scholarly article

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10.3233/JHD-130058

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2

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2

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2013-01-01T00:00:00Z

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24683430

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Huntington disease

protein ubiquitination

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3966139

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