The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms.
about
Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications.Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse.Meningeal blood flow is controlled by H2 S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway.A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction.Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure.NO and HNO donors, nitrones, and nitroxides: Past, present, and future.
P2860
The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2014
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The concomitant coronary vasod ...... t and -independent mechanisms.
@en
The concomitant coronary vasod ...... t and -independent mechanisms.
@nl
type
label
The concomitant coronary vasod ...... t and -independent mechanisms.
@en
The concomitant coronary vasod ...... t and -independent mechanisms.
@nl
prefLabel
The concomitant coronary vasod ...... t and -independent mechanisms.
@en
The concomitant coronary vasod ...... t and -independent mechanisms.
@nl
P2093
P2860
P356
P1476
The concomitant coronary vasod ...... nt and -independent mechanisms
@en
P2093
Barbara K Kemp-Harper
Chengxue Qin
Kai Yee Chin
P2860
P304
P356
10.1111/BPH.12568
P407
P577
2014-04-01T00:00:00Z