The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. - Wikidata - awgldk - TriplyDB

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.

http://www.wikidata.org/entity/Q37666378

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Suppression of basal and carbon nanotube-induced oxidative stress, inflammation and fibrosis in mouse lungs by Nrf2 Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal Nrf2 as a master regulator of tissue damage control and disease tolerance to infection Evolving roles of circadian rhythms in liver homeostasis and pathology Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases The mammalian circadian clock and its entrainment by stress and exercise Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression Circadian molecular clock in lung pathophysiology Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis Cellular mechano-environment regulates the mammary circadian clock Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells Non-thermal plasma activates human keratinocytes by stimulation of antioxidant and phase II pathways.Sulforaphane prevents bleomycin‑induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2‑related factor‑2 activation.Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases Circadian clock: linking epigenetics to aging.Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1.Circadian clock and photoperiodic response in Arabidopsis: from seasonal flowering to redox homeostasis.Aging alters circadian regulation of redox in Drosophila.Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies.Circadian variations in the liver metabolites of medaka (Oryzias latipes).Macrophages and Iron Metabolism.Circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent mechanisms Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease Circadian redox oscillations and metabolism.The timing of caffeic acid treatment with cisplatin determines sensitization or resistance of ovarian carcinoma cell lines.Sleep and Breathing … and Cancer?Role of the Nrf2 signaling system in health and disease.Promising new treatment targets in patients with fibrosing lung disorders.Current frontiers in systemic sclerosis pathogenesis.Circadian systems biology in Metazoa.Non-alcoholic fatty liver disease as a consequence of autonomic imbalance and circadian desynchronization.Interplay between cellular redox oscillations and circadian clocks.Circadian adaptation to cell injury stresses: a crucial interplay of BMAL1 and HSF1.The Pentose Phosphate Pathway Regulates the Circadian Clock Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations.Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.Spatial perspectives in the redox code-Mass spectrometric proteomics studies of moonlighting proteins.BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.

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P2860

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.

http://www.wikidata.org/entity/Q37666378

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on March 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The circadian clock regulates ...... o modulate pulmonary fibrosis.

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The circadian clock regulates ...... o modulate pulmonary fibrosis.

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The circadian clock regulates ...... o modulate pulmonary fibrosis.

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The circadian clock regulates ...... o modulate pulmonary fibrosis.

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The circadian clock regulates ...... o modulate pulmonary fibrosis.

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The circadian clock regulates ...... o modulate pulmonary fibrosis.

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Genes & Development

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The circadian clock regulates ...... to modulate pulmonary fibrosis

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Aya Sagami

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Baoqiang Guo

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Dharshika Pathiranage

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Hikari Yoshitane

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Jefferson Chan

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Keiko Taguchi

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Masayuki Yamamoto

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Nan Yang

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Yoshitaka Fukada

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P2860

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Circadian rhythms persist without transcription in a eukaryote

Peroxiredoxins are conserved markers of circadian rhythms

Circadian regulation of response to oxidative stress in Drosophila melanogaster

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

Coordination of circadian timing in mammals

Coordinated transcription of key pathways in the mouse by the circadian clock

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10.1101/GAD.237081.113

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6

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28

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David A. Bechtold

Gijsbertus van der Horst

Vanja Pekovic-Vaughan

Andrew S Loudon

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2014-03-01T00:00:00Z

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260874375

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24637114

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circadian rhythm

pulmonary fibrosis

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3967045

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