Relation of spontaneous transformation in cell culture to adaptive growth and clonal heterogeneity.
about
Viruses and human cancers: a long road of discovery of molecular paradigms.Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysisPhysiological induction and reversal of focus formation and tumorigenicity in NIH 3T3 cells.Adaptive mutations in Escherichia coli as a model for the multiple mutational origins of tumors.Heritable, population-wide damage to cells as the driving force of neoplastic transformation.Cellular epigenetics: topochronology of progressive "spontaneous" transformation of cells under growth constraint.Selective nature of phorbol 12-myristate 13-acetate-induced neoplastic transformation in NIH 3T3 cells.A critical test of the role of population density in producing transformation.Metastatic conversion of cells by expression of human papillomavirus type 16 E6 and E7 genes.Automatic enumeration and characterization of heterogeneous clonal progression in cell transformation.Cellular epigenetics: effects of passage history on competence of cells for "spontaneous" transformation.Adaptive evolution of degrees and kinds of neoplastic transformation in cell culturePromotion and selection by serum growth factors drive field cancerization, which is anticipated in vivo by type 2 diabetes and obesitySensitivity of transformation to small differences in population density during serial passage of NIH 3T3 cells.Cellular epigenetics: control of the size, shape, and spatial distribution of transformed foci by interactions between the transformed and nontransformed cells.High rate of diversification and reversal among subclones of neoplastically transformed NIH 3T3 clones.Growth in high serum concentrations leads to rapid deadaptation of cells previously adapted to growth in an extremely low concentration of serum.Role of transfection and clonal selection in mediating radioresistanceDynamics of cell transformation in culture and its significance for tumor development in animals.CHO DUKX cell lineages preadapted to growth in serum-free suspension culture enable rapid development of cell culture processes for the manufacture of recombinant proteins.Phenotypic selection as the biological mode of epigenetic conversion and reversion in cell transformation.
P2860
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P2860
Relation of spontaneous transformation in cell culture to adaptive growth and clonal heterogeneity.
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1990
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Relation of spontaneous transf ...... owth and clonal heterogeneity.
@en
Relation of spontaneous transf ...... owth and clonal heterogeneity.
@nl
type
label
Relation of spontaneous transf ...... owth and clonal heterogeneity.
@en
Relation of spontaneous transf ...... owth and clonal heterogeneity.
@nl
prefLabel
Relation of spontaneous transf ...... owth and clonal heterogeneity.
@en
Relation of spontaneous transf ...... owth and clonal heterogeneity.
@nl
P2093
P2860
P356
P1476
Relation of spontaneous transf ...... owth and clonal heterogeneity.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.1.482
P407
P577
1990-01-01T00:00:00Z