Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.
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Identification and preliminary characterization of protein-cysteine farnesyltransferaseBiochemical properties of the ras-related YPT protein in yeast: a mutational analysis.Kos1, a nonreceptor tyrosine kinase that suppresses Ras signalingComparison of the computed structures for the phosphate-binding loop of the p21 protein containing the oncogenic site Gly 12 with the X-ray crystallographic structures for this region in the p21 protein and EFtu. A model for the structure of the p21Ras history: The saga continues.Protein structure and cancer.The ras-related mouse ypt1 protein can functionally replace the YPT1 gene product in yeast.pTAR-encoded proteins in plasmid partitioning.Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR.Cellular oncogenes in neoplasiaDeletion mutants of Harvey ras p21 protein reveal the absolute requirement of at least two distant regions for GTP-binding and transforming activities.Transforming p21 ras protein: flexibility in the major variable region linking the catalytic and membrane-anchoring domains.What we could do now: molecular pathology of colorectal cancer.Aberrant transmembrane signal transduction in Dictyostelium cells expressing a mutated ras gene.Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.Isolation of ras GTP-binding mutants using an in situ colony-binding assay.Mutations of the ras gene product p21 that abolish guanine nucleotide binding.RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally.Decreased expression of Ras GTPase activating protein in human trophoblastic tumors.Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein.Abundant expression of ras proteins in Aplysia neurons.NMR-based functional profiling of RASopathies and oncogenic RAS mutations.Transforming ras proteins accelerate hormone-induced maturation and stimulate cyclic AMP phosphodiesterase in Xenopus oocytesH-ras mutants lacking the epitope for the neutralizing monoclonal antibody Y13-259 show decreased biological activity and are deficient in GTPase-activating protein interaction.Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins.Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.A single point mutation of Ala-25 to Asp in the 14,000-Mr envelope protein of vaccinia virus induces a size change that leads to the small plaque size phenotype of the virus.Microinjection of transforming ras protein induces c-fos expressionNeutralizing monoclonal antibody against ras oncogene product p21 which impairs guanine nucleotide exchangeCharacterization of a factor that stimulates hydrolysis of GTP bound to ras gene product p21 (GTPase-activating protein) and correlation of its activity to cell densityNucleotide sequence and biochemical activities of the Moloney murine sarcoma virus strain HT-1 mos gene.Expression of the Kirsten ras viral and human proteins in Escherichia coli.Proteolytic processing of avian sarcoma and leukosis viruses pol-endo recombinant proteins reveals another pol gene domain.rasH mutants deficient in GTP binding.Activation of ras p21 transforming properties associated with an increase in the release rate of bound guanine nucleotide.Direct identification of palmitic acid as the lipid attached to p21ras.Monoclonal antibody Y13-259 recognizes an epitope of the p21 ras molecule not directly involved in the GTP-binding activity of the proteinA transforming ras gene can provide an essential function ordinarily supplied by an endogenous ras gene.Mutational analysis of a ras catalytic domain.Structural significance of the GTP-binding domain of ras p21 studied by site-directed mutagenesis
P2860
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P2860
Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 1985
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Ha-ras proteins exhibit GTPase ...... in decreased GTPase activity.
@en
Ha-ras proteins exhibit GTPase ...... in decreased GTPase activity.
@nl
type
label
Ha-ras proteins exhibit GTPase ...... in decreased GTPase activity.
@en
Ha-ras proteins exhibit GTPase ...... in decreased GTPase activity.
@nl
prefLabel
Ha-ras proteins exhibit GTPase ...... in decreased GTPase activity.
@en
Ha-ras proteins exhibit GTPase ...... in decreased GTPase activity.
@nl
P2093
P2860
P356
P1476
Ha-ras proteins exhibit GTPase ...... in decreased GTPase activity.
@en
P2093
P2860
P304
P356
10.1073/PNAS.82.2.376
P407
P577
1985-01-01T00:00:00Z