What should be considered on design of a colon-specific prodrug?

What should be considered on design of a colon-specific prodrug?

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http://www.wikidata.org/entity/Q37679957
Nanomedicine in GICelecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery.Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancementEvaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-κB, an anti-inflammatory target.Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes.Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis.Susceptibility of glucocorticoids to colonic metabolism and pharmacologic intervention in the metabolism: implication for therapeutic activity of colon-specific glucocorticoid 21-sulfate sodium at the target site.Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site.Colonic delivery of celecoxib is a potential pharmaceutical strategy for repositioning the selective COX-2 inhibitor as an anti-colitic agent.Colon-specific delivery of celecoxib is a potential strategy to improve toxicological and pharmacological properties of the selective Cox-2 inhibitor: implication in treatment of familiar adenomatous polyposis.Synthesis and evaluation of sulfate conjugated metronidazole as a colon-specific prodrug of metronidazole.
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What should be considered on design of a colon-specific prodrug?

Item
http://www.wikidata.org/entity/Q37679957
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
What should be considered on design of a colon-specific prodrug?
@en
What should be considered on design of a colon-specific prodrug?
@nl
type
label
What should be considered on design of a colon-specific prodrug?
@en
What should be considered on design of a colon-specific prodrug?
@nl
prefLabel
What should be considered on design of a colon-specific prodrug?
@en
What should be considered on design of a colon-specific prodrug?
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
What should be considered on design of a colon-specific prodrug?
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698