Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity. - Wikidata - awgldk - TriplyDB

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

http://www.wikidata.org/entity/Q37695433

about

RB1: a prototype tumor suppressor and an enigma Drugging the addict: non-oncogene addiction as a target for cancer therapy Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis.Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells.Antitumor mechanisms when pRb and p53 are genetically inactivated.RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy.p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation.Treating cancer when pRb and p53 cannot be reactivated.SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells.The bone marrow metastasis niche in retinoblastoma.Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer

P2860

Q26866393-ABC91B7D-019A-4999-BC82-FF30B4E2BC46 Q28079559-80EEAD9A-F6A5-41AA-906E-F95156E86045 Q30278581-DA24358A-9B24-4FB3-AEEF-380F43294460 Q35126704-17C48CBD-598B-45B6-BC18-A1F55BF34F3E Q36561595-D5FDCB6B-006D-40DE-BB0F-082A63D264C7 Q36876207-E2303FA6-8F51-4C03-A018-1740FA34A527 Q36962536-24D7A8BE-DDE9-42AC-8450-7C96ACFB58C3 Q38285170-B426DF53-C2CF-4C92-BEC0-6D1376625EAE Q38544737-6668FFC4-7C55-48D5-BF69-F62DBAAD0457 Q38770759-3CA81C44-11AF-4BB9-8A4B-F1D3A93B0575 Q42024743-E1BE9219-6426-46CC-A6D4-9AB4E48E8C4B Q42205712-E7685455-3DCA-4195-A45A-86D84098F776 Q47567989-62FA8132-0F38-4CB0-BFF8-E3A351742827 Q53471802-FAAFA140-6C66-44BB-945C-AC531A5E1D58 Q58623046-B886C013-EADE-4FB1-BF20-D056B2CCE886

P2860

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

http://www.wikidata.org/entity/Q37695433

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 17 March 2014

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

@en

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

@nl

type

label

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

@en

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

@nl

prefLabel

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

@en

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

@nl

P1433

Q37695433-35AF0A54-DC42-48B8-A2EC-E14B391FC942

P1476

Q37695433-16C62AE1-14BE-4718-ADE7-90ED8BF7D1D4

P2093

Q37695433-0E39C093-43E0-451B-94F7-00A69B3A1C67

Q37695433-3872D050-7D71-4A3D-A56F-81AB956ECDE2

Q37695433-3CF288C7-9EE5-46E2-8C2D-5C6EB684ECAD

Q37695433-66D17332-924C-4F33-AA2B-90CA456768B1

Q37695433-89D123EA-2D4F-4B36-9203-49DB743C7FD3

Q37695433-9D594C16-FA8A-47A0-A0EF-B0785418DC02

Q37695433-F33515ED-77E9-4F95-9528-89EC3A682939

Q37695433-F9579D92-45E4-4EF4-86A9-955AB5B6A7F5

P2860

Q37695433-02279779-CD5D-43CB-84FC-326F1375CE85

Q37695433-02826ED2-4007-4C74-845F-8ED0A7FE1886

Q37695433-06FC1432-F5D5-42A5-B6A7-BD9F24FB928A

Q37695433-07FDDD93-D7D4-4D66-B96E-63A6B922CBB2

Q37695433-0E6CF4DC-96AB-46B5-8D8E-F20B449248A8

Q37695433-1427E040-4180-4C60-AB87-5211F9B7A522

Q37695433-17E60AAB-B9AB-417B-90DD-6871CB79D1F9

Q37695433-17F49085-FA74-4135-B87B-BB2849FF6449

Q37695433-198BE9E8-4582-44FD-ACBE-934ACE72BD84

Q37695433-1A46117A-8D73-4AA0-8B50-11CDE4C01B9C

P2888

Q37695433-0367067A-30B4-481D-B47B-3004EFEE507C

P304

Q37695433-41ECCA0C-67DA-4AEB-87F0-87CEC0DC4D10

P31

Q37695433-3A593E0D-3742-42A6-B0E0-03E75EDD4508

P356

Q37695433-EAAE261C-B0A0-4D34-9714-002C81526DD3

P407

Q37695433-4ABFC41B-C268-4600-ADF0-367510B7726C

P478

Q37695433-3B36D20A-7C26-4421-B9C0-E7F0B67ED5A9

P577

Q37695433-4E15EC87-97F0-433D-BCEF-A029563904A0

P5875

Q37695433-C13DC676-5CA9-4D2E-B2C8-31CCAE3E1B1F

P6179

Q37695433-F507EB4C-62B3-4757-AAF2-574C62D91AE2

P698

Q37695433-62AEF999-DCA4-4B3D-B990-38B1ED37848B

P921

Q37695433-904DDE3F-D184-498F-AD0F-4E94CC233990

P932

Q37695433-917CB583-3B46-4939-A17A-520E16FDF147

P356

P1433

Nature Communications

P1476

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

@en

P2093

Frederick Bauzon

http://www.w3.org/2001/XMLSchema#string

Hao Fu

http://www.w3.org/2001/XMLSchema#string

Hongling Zhao

http://www.w3.org/2001/XMLSchema#string

Jinhua Cui

http://www.w3.org/2001/XMLSchema#string

Keiich I Nakayama

http://www.w3.org/2001/XMLSchema#string

Keiko Nakayama

http://www.w3.org/2001/XMLSchema#string

Liang Zhu

http://www.w3.org/2001/XMLSchema#string

Zhonglei Lu

http://www.w3.org/2001/XMLSchema#string

P2860

The ubiquitin-protein ligase Itch regulates p73 stability

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase

Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila

P2888

P304

3463

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NCOMMS4463

http://www.w3.org/2001/XMLSchema#string

P407

P478

5

http://www.w3.org/2001/XMLSchema#string

P577

2014-03-17T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

260841085

http://www.w3.org/2001/XMLSchema#string

P6179

1029300412

http://www.w3.org/2001/XMLSchema#string

P698

24632684

http://www.w3.org/2001/XMLSchema#string

P921

apoptotic process

P932

3982150

http://www.w3.org/2001/XMLSchema#string