The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.
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Mitoxantrone and Analogues Bind and Stabilize i-Motif Forming DNA Sequences.Pressure-dependent formation of i-motif and G-quadruplex DNA structures.Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LLA G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancerUnfolding Kinetics of the Human Telomere i-Motif Under a 10 pN Force Imposed by the α-Hemolysin Nanopore Identify Transient Folded-State Lifetimes at Physiological pH.Long-Lived Excited-State Dynamics of i-Motif Structures Probed by Time-Resolved Infrared Spectroscopy.Anti-sense DNA d(GGCCCC)n expansions in C9ORF72 form i-motifs and protonated hairpins.Porphyrin Bound to i-Motifs: Intercalation versus External Groove Binding.GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1Stabilization of i-motif structures by 2'-β-fluorination of DNA.A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription.Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition.The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules.Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif.Conformational diversity of single-stranded DNA from bacterial repetitive extragenic palindromes: Implications for the DNA recognition elements of transposases.The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective TargetNucleic Acid i-Motif Structures in Analytical Chemistry.Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics.Label-free DNA-based biosensors using structure-selective light-up dyes.Formation and processing of DNA damage substrates for the hNEIL enzymes.Identification of multiple genomic DNA sequences which form i-motif structures at neutral pHReversible DNA i-motif to hairpin switching induced by copper(II) cations.The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifsThe effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.The importance of loop length on the stability of i-motif structures.Preferential targeting of i-motifs and G-quadruplexes by small molecules.Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression.Identification of new DNA i-motif binding ligands through a fluorescent intercalator displacement assay.Evaluation of stability of DNA i-motifs in the nuclei of living mammalian cells.BmILF and i-motif structure are involved in transcriptional regulation of BmPOUM2 in Bombyx mori.Topological impact of noncanonical DNA structures on Klenow fragment of DNA polymerase.From direct to indirect lithium targets: a comprehensive review of omics data.Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.Human DNA Repair Genes Possess Potential G-Quadruplex Sequences in Their Promoters and 5'-Untranslated Regions.Probing Synergistic Effects of DNA Methylation and 2'-β-Fluorination on i-Motif Stability.Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks.Neutral red as a specific light-up fluorescent probe for i-motif DNA.i-Clamp phenoxazine for the fine tuning of DNA i-motif stability.Improved i-motif thermal stability by insertion of anthraquinone monomers.Probing structural changes of self assembled i-motif DNA.
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P2860
The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The dynamic character of the B ...... rnative DNA hairpin structure.
@en
The dynamic character of the B ...... rnative DNA hairpin structure.
@nl
type
label
The dynamic character of the B ...... rnative DNA hairpin structure.
@en
The dynamic character of the B ...... rnative DNA hairpin structure.
@nl
prefLabel
The dynamic character of the B ...... rnative DNA hairpin structure.
@en
The dynamic character of the B ...... rnative DNA hairpin structure.
@nl
P2093
P2860
P356
P1476
The dynamic character of the B ...... rnative DNA hairpin structure.
@en
P2093
Danzhou Yang
Hyun-Jin Kang
Laurence H Hurley
Manikandadas M Madathil
Mohammad P Alam
Prashansa Agrawal
Samantha Kendrick
Sidney M Hecht
Vijay Gokhale
P2860
P304
P356
10.1021/JA410934B
P407
P577
2014-03-07T00:00:00Z