Microtubule binding distinguishes dystrophin from utrophin. - Wikidata - awgldk - TriplyDB

Microtubule binding distinguishes dystrophin from utrophin.

Microtubule binding distinguishes dystrophin from utrophin.

http://www.wikidata.org/entity/Q37711984

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Dystrophin and the two related genetic diseases, Duchenne and Becker muscular dystrophies Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle Altered nuclear dynamics in MDX myofibers.The Dystrophin Complex: Structure, Function, and Implications for Therapy Oxidative stress decreases microtubule growth and stability in ventricular myocytes Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice.Recovery of altered neuromuscular junction morphology and muscle function in mdx mice after injury Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins.In vitro stability of therapeutically relevant, internally truncated dystrophins.Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo.Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles.2015 William Allan Award.Prospect of gene therapy for cardiomyopathy in hereditary muscular dystrophy.The Skeletal Muscle Environment and Its Role in Immunity and Tolerance to AAV Vector-Mediated Gene Transfer.Advances in genetic therapeutic strategies for Duchenne muscular dystrophy.Viral vector-mediated gene therapies.Dual AAV gene therapy for Duchenne muscular dystrophy with a 7-kb mini-dystrophin gene in the canine model.Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.Second-generation compound for the modulation of utrophin in the therapy of DMD.Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice.Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction.Utrophin regulates modal gating of mechanosensitive ion channels in dystrophic skeletal muscle.Mouse models of two missense mutations in actin binding domain 1 of dystrophin associated with Duchenne or Becker muscular dystrophy.Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies.Eccentric Contraction-Induced Muscle Injury: Reproducible, Quantitative, Physiological Models to Impair Skeletal Muscle's Capacity to Generate Force.NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice.Duchenne and Becker Muscular Dystrophies: A Review of Animal Models, Clinical End Points, and Biomarker Quantification.Microtubule mechanics in the working myocyte.A Simple and Low-cost Assay for Measuring Ambulation in Mouse Models of Muscular Dystrophy.Independent variability of microtubule perturbations associated with dystrophinopathy.Dystrophin's central domain forms a complex filament that becomes disorganized by in-frame deletions.Histological and biochemical outcomes of cardiac pathology in mdx mice with dietary quercetin enrichment.Variable rescue of microtubule and physiological phenotypes in mdx muscle expressing different miniaturized dystrophins.Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation.

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Microtubule binding distinguishes dystrophin from utrophin.

http://www.wikidata.org/entity/Q37711984

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 31 March 2014

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Microtubule binding distinguishes dystrophin from utrophin.

@en

Microtubule binding distinguishes dystrophin from utrophin.

@nl

type

label

Microtubule binding distinguishes dystrophin from utrophin.

@en

Microtubule binding distinguishes dystrophin from utrophin.

@nl

prefLabel

Microtubule binding distinguishes dystrophin from utrophin.

@en

Microtubule binding distinguishes dystrophin from utrophin.

@nl

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PNAS.1323842111

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Proceedings of the National Academy of Sciences of the United States of America

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Microtubule binding distinguishes dystrophin from utrophin.

@en

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Dana M Strandjord

http://www.w3.org/2001/XMLSchema#string

Dawn A Lowe

http://www.w3.org/2001/XMLSchema#string

Glen B Banks

http://www.w3.org/2001/XMLSchema#string

James M Ervasti

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Joseph J Belanto

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Melissa K Gardner

http://www.w3.org/2001/XMLSchema#string

Michael D Eckhoff

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Tara L Mader

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P2860

Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts

An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex

The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein

The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin

Costameres: the Achilles' heel of Herculean muscle

CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta

A vinculin-containing cortical lattice in skeletal muscle: transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemma

Costameres are sites of force transmission to the substratum in adult rat cardiomyocytes

The WW domain: a signalling site in dystrophin?

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5723-5728

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scholarly article

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10.1073/PNAS.1323842111

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15

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111

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2014-03-31T00:00:00Z

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24706788

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3992671

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