Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis.
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Development of Species-Specific Ah Receptor-Responsive Third Generation CALUX Cell Lines with Enhanced Responsiveness and Improved Detection LimitsDeciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR TransformationAccess Path to the Ligand Binding Pocket May Play a Role in Xenobiotics Selection by AhRA Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding DomainAn Aryl Hydrocarbon Receptor from the Salamander Ambystoma mexicanum Exhibits Low Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxinLigand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs.Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functionsInhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner.Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice.Feedback control of AHR signalling regulates intestinal immunity.Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells.Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice.Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling.Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291.Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome.Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity.Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 Expression.Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones.Aryl Hydrocarbon Receptor Diet and Breast Cancer Risk.Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor AgonistSustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma
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Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 03 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Ligand promiscuity of aryl hyd ...... by site-directed mutagenesis.
@en
Ligand promiscuity of aryl hyd ...... by site-directed mutagenesis.
@nl
type
label
Ligand promiscuity of aryl hyd ...... by site-directed mutagenesis.
@en
Ligand promiscuity of aryl hyd ...... by site-directed mutagenesis.
@nl
prefLabel
Ligand promiscuity of aryl hyd ...... by site-directed mutagenesis.
@en
Ligand promiscuity of aryl hyd ...... by site-directed mutagenesis.
@nl
P2860
P356
P1476
Ligand promiscuity of aryl hyd ...... by site-directed mutagenesis.
@en
P2093
Anatoly A Soshilov
Michael S Denison
P2860
P304
P356
10.1128/MCB.01183-13
P407
P577
2014-03-03T00:00:00Z