TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice.
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Modeling Influenza Virus Infection: A Roadmap for Influenza ResearchDESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus.Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.A serpin shapes the extracellular environment to prevent influenza A virus maturationA mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region.Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidantsCathepsin L Helps to Defend Mice from Infection with Influenza A.Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection.Role of Host Genes in Influenza Virus Replication.In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.Modification of the hemagglutinin cleavage site allows indirect activation of avian influenza virus H9N2 by bacterial staphylokinaseZygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs.TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice
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TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 February 2014
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vedecký článok
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vetenskaplig artikel
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TMPRSS2 is a host factor that ...... 7N9 influenza A virus in mice.
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TMPRSS2 is a host factor that ...... 7N9 influenza A virus in mice.
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type
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TMPRSS2 is a host factor that ...... 7N9 influenza A virus in mice.
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TMPRSS2 is a host factor that ...... 7N9 influenza A virus in mice.
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TMPRSS2 is a host factor that ...... 7N9 influenza A virus in mice.
@en
TMPRSS2 is a host factor that ...... 7N9 influenza A virus in mice.
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TMPRSS2 is a host factor that ...... 7N9 influenza A virus in mice.
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Annette Preuss
Annika Arendt
Carolin Tarnow
Eva Böttcher-Friebertshäuser
Folker Schwalm
Géraldine Engels
Hanna Sediri
Peter S Nelson
Wolfgang Garten
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10.1128/JVI.03799-13
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2014-02-12T00:00:00Z