Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.
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Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistanceMolecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxideGenomic cloning and characterization of the rat glutathione S-transferase-A3-subunit geneProbing subunit interactions in alpha class rat liver glutathione S-transferase with the photoaffinity label glutathionyl S-[4-(succinimidyl)benzophenone]Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalanModeling the chemoprotective functions of glutathione S-transferases in cultured cell lines by heterologous expression.Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.Pharmacogenomics of cisplatin-induced ototoxicityGlutathione transferases and cancer.Do glutathione and related enzymes play a role in drug resistance in small cell lung cancer cell lines?Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.Modulation of cisplatin cytotoxicity by sulphasalazineCharacterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changesCisplatin nephrotoxicity: molecular mechanisms.Functional antioxidant responsive elements.Rapid detection of inducers of enzymes that protect against carcinogens.Nucleoside salvage and resistance to antimetabolite anticancer agents.Non-Hodgkin's B-cell lymphoma: advances in molecular strategies targeting drug resistance.Adhesion molecules in host defense.Antineoplastic drug resistance and breast cancer.Transcriptional and post-transcriptional mechanisms can regulate cell-specific expression of the human Pi-class glutathione S-transferase gene.Functional characterization of the transcription silencer element located within the human Pi class glutathione S-transferase promoter.Sp1-mediated transcriptional activation of the human Pi class glutathione S-transferase promoter.Establishment and characterization of acquired resistance to platinum anticancer drugs in human ovarian carcinoma cells.Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid.Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancerChlorambucil-monoglutathionyl conjugate is sequestered by human alpha class glutathione S-transferases.Co-variation of glutathione transferase expression and cytostatic drug resistance in HeLa cells: establishment of class Mu glutathione transferase M3-3 as the dominating isoenzyme.The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy.A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines.Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutantGlutathione analogue sorbents selectively bind glutathione S-transferase isoenzymes.Establishment by adriamycin exposure of multidrug-resistant rat ascites hepatoma AH130 cells showing low DT-diaphorase activity and high cross resistance to mitomycins.Variability of glutathione S-transferase isoenzyme patterns in matched normal and cancer human breast tissue.Significance of nuclear glutathione S-transferase pi in resistance to anti-cancer drugs.Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells.Main drug-metabolizing enzyme systems in human non-Hodgkin's lymphomas sensitive or resistant to chemotherapy.
P2860
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P2860
Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Expression of recombinant glut ...... sistance to alkylating agents.
@en
Expression of recombinant glut ...... sistance to alkylating agents.
@nl
type
label
Expression of recombinant glut ...... sistance to alkylating agents.
@en
Expression of recombinant glut ...... sistance to alkylating agents.
@nl
prefLabel
Expression of recombinant glut ...... sistance to alkylating agents.
@en
Expression of recombinant glut ...... sistance to alkylating agents.
@nl
P2860
P356
P1476
Expression of recombinant glut ...... sistance to alkylating agents.
@en
P2093
R B Puchalski
P2860
P304
P356
10.1073/PNAS.87.7.2443
P407
P577
1990-04-01T00:00:00Z