After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.
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Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.p53 Family and Cellular Stress Responses in Cancer.Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch.Bax modulates neuronal survival while p53 is unaltered after Cytochrome C induced oxidative stress in the adult olfactory bulb in vivo.Ceramide channels: destabilization by Bcl-xL and role in apoptosisBax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric speciesBH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranesRedefining the BH3 Death Domain as a 'Short Linear Motif'.Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xLDissociation of Bak α1 helix from the core and latch domains is required for apoptosis.Anti-apoptotic response during anoxia and recovery in a freeze-tolerant wood frog (Rana sylvatica)An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway.Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.Structural model of active Bax at the membrane.miRNA‑1284 inhibits cell growth and induces apoptosis of lung cancer cells.MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers.BCL-2 family proteins: changing partners in the dance towards death.Why do BCL-2 inhibitors work and where should we use them in the clinic?E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.Bax retrotranslocation potentiates Bcl-xL's antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance.Blue light-induced apoptosis of human promyelocytic leukemia cells via the mitochondrial-mediated signaling pathway.
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After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
After embedding in membranes a ...... itochondrial permeabilization.
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After embedding in membranes a ...... itochondrial permeabilization.
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type
label
After embedding in membranes a ...... itochondrial permeabilization.
@en
After embedding in membranes a ...... itochondrial permeabilization.
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prefLabel
After embedding in membranes a ...... itochondrial permeabilization.
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After embedding in membranes a ...... itochondrial permeabilization.
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P2093
P2860
P50
P356
P1476
After embedding in membranes a ...... mitochondrial permeabilization
@en
P2093
Chengguo Xing
Domina Falcone
Jamie McNichol
Jialing Lin
Jingzhen Ding
Xuejun C Zhang
P2860
P304
11873-11896
P356
10.1074/JBC.M114.552562
P407
P577
2014-03-10T00:00:00Z