The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy.
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The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancersPKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondriaMYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation.Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseasesYin Yang gene expression ratio signature for lung cancer prognosisRole of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)Identification of cytotoxic drugs that selectively target tumor cells with MYC overexpressionDrug target prediction and repositioning using an integrated network-based approachInhibitor of MYC identified in a Kröhnke pyridine libraryThe enforced expression of c-Myc in pig fibroblasts triggers mesenchymal-epithelial transition (MET) via F-actin reorganization and RhoA/Rock pathway inactivationTransient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and SelolCD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheresInhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia.Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma.Senescent cells and their secretory phenotype as targets for cancer therapy.Reciprocal activation of transcription factors underlies the dichotomy between proliferation and invasion of glioma cells.Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.Elevation of c-MYC disrupts HLA class II-mediated immune recognition of human B cell tumorsA cell-based high-throughput screen addressing 3'UTR-dependent regulation of the MYCN gene.Targeting of the MYCN protein with small molecule c-MYC inhibitorsSmall molecules targeting c-Myc oncogene: promising anti-cancer therapeuticsPrognostic Value of Beta-Tubulin-3 and c-Myc in Muscle Invasive Urothelial Carcinoma of the Bladder.Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cellsATF2 - at the crossroad of nuclear and cytosolic functions.Circadian gene expression predicts patient response to neoadjuvant chemoradiation therapy for rectal cancer.Dissecting the complex regulation of Mad4 in glioblastoma multiforme cells.Regulation of human RNase-L by the miR-29 family reveals a novel oncogenic role in chronic myelogenous leukemiaInhibition of Myc family proteins eradicates KRas-driven lung cancer in miceRNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.WNT/β-Catenin signaling pathway regulates non-tumorigenesis of human embryonic stem cells co-cultured with human umbilical cord mesenchymal stem cells.Cdk2: a key regulator of the senescence control function of Myc.Caspases and cancer.Tristetraprolin: roles in cancer and senescence.Oncoprotein stabilization in brain tumors.Development of anticancer drugs based on the hallmarks of tumor cells.Targeting RNA polymerase I to treat MYC-driven cancer.STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence.Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation.
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P2860
The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 April 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The Yin and Yang functions of ...... nt and as targets for therapy.
@en
The Yin and Yang functions of ...... nt and as targets for therapy.
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type
label
The Yin and Yang functions of ...... nt and as targets for therapy.
@en
The Yin and Yang functions of ...... nt and as targets for therapy.
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prefLabel
The Yin and Yang functions of ...... nt and as targets for therapy.
@en
The Yin and Yang functions of ...... nt and as targets for therapy.
@nl
P1476
The Yin and Yang functions of ...... nt and as targets for therapy.
@en
P2093
Lars-Gunnar Larsson
Marie Arsenian Henriksson
P304
P356
10.1016/J.YEXCR.2010.03.025
P407
P577
2010-04-09T00:00:00Z