Mutational analysis of allosteric activation and inhibition of glucokinase.

Mutational analysis of allosteric activation and inhibition of glucokinase.

Item
http://www.wikidata.org/entity/Q37733839
A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activatorsAnalysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescenceThermal stability of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and ureaGeneration of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.Impact of mutations on the allosteric conformational equilibrium.Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic β-cells.Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein.Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus.Heterogeneity in phenotype of hyperinsulinism caused by activating glucokinase mutations: a novel mutation and its functional characterization.Tryptophan Fluorescence Yields and Lifetimes as a Probe of Conformational Changes in Human Glucokinase.
P2860

Mutational analysis of allosteric activation and inhibition of glucokinase.

Item
http://www.wikidata.org/entity/Q37733839
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mutational analysis of allosteric activation and inhibition of glucokinase.
@en
Mutational analysis of allosteric activation and inhibition of glucokinase.
@nl
type
label
Mutational analysis of allosteric activation and inhibition of glucokinase.
@en
Mutational analysis of allosteric activation and inhibition of glucokinase.
@nl
prefLabel
Mutational analysis of allosteric activation and inhibition of glucokinase.
@en
Mutational analysis of allosteric activation and inhibition of glucokinase.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Mutational analysis of allosteric activation and inhibition of glucokinase.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932