Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality.

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Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality.

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scientific article published on 04 August 2014

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Transgenic expression of the N ...... dominant embryonic lethality.

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Transgenic expression of the N525S-tuberin variant in Tsc2 mutant

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Transgenic expression of the N ...... dominant embryonic lethality.

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Transgenic expression of the N525S-tuberin variant in Tsc2 mutant

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Transgenic expression of the N ...... dominant embryonic lethality.

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Transgenic expression of the N525S-tuberin variant in Tsc2 mutant

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Transgenic expression of the N ...... dominant embryonic lethality.

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Chikashi Ishioka

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Masatoshi Shiono

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Masatsugu Ueda

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Okio Hino

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Riichi Takahashi

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Toshiyuki Kobayashi

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P2860

Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis.

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

Targeting the mTOR signaling network for cancer therapy

Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

Identification and characterization of the tuberous sclerosis gene on chromosome 16

A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice

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srep05927

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scholarly article

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10.1038/SREP05927

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English

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2014-08-04T00:00:00Z

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264502135

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25088526

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